Validation of the Vascular quality of life questionnaire – 6 for clinical use in patients with lower limb peripheral arterial disease

Table 2 Quality of life summary scores, arterial pressure indices and walking capacity at baseline and follow-up

	All participants (n = 171)	Conservative treatment (n = 68)			Invasive treatment (n = 73)			No follow-up (n = 30)
	Baseline	Baseline	Follow-up		Baseline	Follow-up		Baseline
	Mean (95% CI)	Mean (95% CI)	Mean (95% CI)	p	Mean (95% CI)	Mean (95% CI)	p	Mean (95% CI)
VQ-6 sum	12.7 (12.2–13.3)	13.6 (12.8–14.4)	15.2 (14.3–16.1)	0.001 ^b	12.1 (11.4–12.8)	19.6 (15.8–18.0)	0.001 ^b	12.4 (10.7–14.0)
SF-36 PCS	33 (32–34)	35 (33–36)	38 (36–40)	0.001 ^b	32 (30–33)	40 (37–42)	0.001 ^b	32 (30–35)
SF-36 MCS	48 (47–50)	51 (48–53)	48 (45–51)	0.470 ^b	48 (45–51)	48 (46–51)	0.780 ^b	45 (40–50)
ABI^a	0.62 (0.59–0.65)	0.65 (0.62–0.69)	0.67 (0.63–0.71)	0.394 ^b	0.57 (0.52–0.62)	0.76 (0.71–0.82)	0.001 ^b	0.64 (0.57–0.72)
ABI pe^a	0.47 (0.43–0.51)	0.55 (0.50–0.60)	0.53 (0.47–0.59)	0.597 ^b	0.36 (0.29–0.43)	0.67 (0.60–0.75)	0.001 ^b	0.54 (0.42–0.67)
	Median (IQ)	Median (IQ)	Median (IQ)		Median (IQ)	Median (IQ)		Median (IQ)
ICD	87 (46–133)	100 (55–159)	107 (10–600)	0.036 ^c	62 (40–100)	110 (0–295)	0.001 ^c	110 (53–145)
MWD	400 (164–410)	410 (260–418)	410 (30–650)	0.066 ^c	233 (110–400)	403 (30–570)	0.001 ^c	410 (240–420)

VQ-6 –Vascular Quality of Life Questionnarie-6, SF-36 –Short Form-36, PCS –Physical component summary score, MCS –Mental component summary score, ABI -ankle-brachial index, pe –postexercise, ICD –intermittent claudication distance, MWD –maximum walking distance, IQ –interquartile range (25th–75th percentile)
^aSymptomatic leg
^bTwo-tailed t-test for normally distributed data, p < 0.05 was regarded significant
^cWilcoxon signed rank test for non-normally distributed data, p < 0.05 was regarded significant

ISSN: 1477-7525