From: Healthcare utilization and costs for patients initiating Dabigatran or Warfarin
Pre-PSM | Post-PSM | |||||
---|---|---|---|---|---|---|
Measure | Dabigatran | Warfarin | P value | Dabigatran | Warfarin | P value |
N | 1127 | 3234 | 1110 | 1110 | ||
Age, years | ||||||
Mean ± SD | 75.0 ± 6.9 | 75.3 ± 7.4 | 0.3414 | 75.1 ± 6.9 | 75.0 ± 7.0 | 0.5682 |
Median, [Min – Max] | 75 [42–89] | 76 [40–89] | 75 [42–89] | 75 [46–89] | ||
Male, n (%) | 579 (51.4) | 1663 (51.4) | 0.9783 | 569 (51.3) | 574 (51.7) | 0.8318 |
Race/Ethnicity, n (%) | ||||||
White | 1043 (92.5) | 2908 (89.9) | 0.0093 | 1028 (92.6) | 1000 (90.1) | 0.0345 |
Other | 84 (7.5) | 326 (10.1) | 82 (7.4) | 110 (9.9) | ||
Geographic Region, n (%) | ||||||
Northeast | 27 (2.4) | 82 (2.5) | <0.0001 | 27 (2.4) | 23 (2.1) | 0.4615 |
Midwest | 254 (22.5) | 1004 (31.0) | 254 (22.9) | 254 (22.9) | ||
South | 764 (67.8) | 1868 (57.8) | 747 (67.3) | 768 (69.2) | ||
West | 82 (7.3) | 280 (8.7) | 82 (7.4) | 65 (5.9) | ||
Baseline Deyo-Charlson Comorbidity Index (DCI) score | 2.1 ± 2.1 | 2.9 ± 2.5 | <0.0001 | 2.1 ± 2.1 | 2.1 ± 2.0 | 0.5809 |
Baseline Elixhauser Comorbidity index (ECI) score | 4.4 ± 2.5 | 5.5 ± 2.7 | <0.0001 | 4.4 ± 2.5 | 4.5 ± 2.4 | 0.3789 |
Baseline stroke risk | ||||||
CHADS2 stroke risk score | 2.3 ± 1.2 | 2.6 ± 1.2 | <0.0001 | 2.3 ± 1.2 | 2.3 ± 1.2 | 0.7783 |
CHA2DS2-VASc stroke risk score | 4.0 ± 1.5 | 4.3 ± 1.5 | <0.0001 | 4.0 ± 1.5 | 4.0 ± 1.5 | 0.8061 |
Baseline bleeding risk | 0.1780 | |||||
HEMORR2HAGES score | 2.4 ± 1.5 | 2.9 ± 1.7 | <0.0001 | 2.4 ± 1.5 | 2.4 ± 1.4 | |
Time from first AF to index (days) | 20 ± 22 | 19 ± 22 | 0.0282 | 20 ± 22 | 18 ± 22 | 0.0559 |
Duration of follow-up (days) | ||||||
Mean ± SD | 346 ± 62 | 339 ± 74 | 0.0010 | 346 ± 62 | 343 ± 68 | 0.3329 |
Median [Range] | 365 [42–365] | 365 [9–365] | 365 [42–365] | 365 [11–365] | ||
Total HCRU pre-index, mean visits per patient [SD] | ||||||
Hospitalization | 0.8 [0.7] | 1.1 [0.9] | <.0001 | 0.8 [0.7] | 0.9 [0.7] | 0.0183 |
ER visit | 0.7 [1.2] | 0.8 [1.5] | 0.3055 | 0.7 [1.3] | 0.7 [1.1] | 0.0603 |
Physician office visit | 12.4 [9.6] | 12.3 [10.3] | 0.7100 | 12.4 [9.7] | 11.6 [9.2] | 0.0293 |
Outpatient visit | 5.7 [6.8] | 7.3 [14.0] | <.0001 | 5.7 [6.8] | 6.1 [11.6] | 0.3758 |