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Table 1 Demographic and clinical characteristics of patients with NVAF treated with dabigatran or warfarin

From: Healthcare utilization and costs for patients initiating Dabigatran or Warfarin

 

Pre-PSM

Post-PSM

Measure

Dabigatran

Warfarin

P value

Dabigatran

Warfarin

P value

N

1127

3234

 

1110

1110

 

Age, years

 Mean ± SD

75.0 ± 6.9

75.3 ± 7.4

0.3414

75.1 ± 6.9

75.0 ± 7.0

0.5682

 Median, [Min – Max]

75 [42–89]

76 [40–89]

75 [42–89]

75 [46–89]

 Male, n (%)

579 (51.4)

1663 (51.4)

0.9783

569 (51.3)

574 (51.7)

0.8318

Race/Ethnicity, n (%)

 White

1043 (92.5)

2908 (89.9)

0.0093

1028 (92.6)

1000 (90.1)

0.0345

 Other

84 (7.5)

326 (10.1)

82 (7.4)

110 (9.9)

Geographic Region, n (%)

 Northeast

27 (2.4)

82 (2.5)

<0.0001

27 (2.4)

23 (2.1)

0.4615

 Midwest

254 (22.5)

1004 (31.0)

254 (22.9)

254 (22.9)

 South

764 (67.8)

1868 (57.8)

747 (67.3)

768 (69.2)

 West

82 (7.3)

280 (8.7)

82 (7.4)

65 (5.9)

Baseline Deyo-Charlson Comorbidity Index (DCI) score

2.1 ± 2.1

2.9 ± 2.5

<0.0001

2.1 ± 2.1

2.1 ± 2.0

0.5809

Baseline Elixhauser Comorbidity index (ECI) score

4.4 ± 2.5

5.5 ± 2.7

<0.0001

4.4 ± 2.5

4.5 ± 2.4

0.3789

Baseline stroke risk

 CHADS2 stroke risk score

2.3 ± 1.2

2.6 ± 1.2

<0.0001

2.3 ± 1.2

2.3 ± 1.2

0.7783

 CHA2DS2-VASc stroke risk score

4.0 ± 1.5

4.3 ± 1.5

<0.0001

4.0 ± 1.5

4.0 ± 1.5

0.8061

Baseline bleeding risk

0.1780

 HEMORR2HAGES score

2.4 ± 1.5

2.9 ± 1.7

<0.0001

2.4 ± 1.5

2.4 ± 1.4

 Time from first AF to index (days)

20 ± 22

19 ± 22

0.0282

20 ± 22

18 ± 22

0.0559

Duration of follow-up (days)

 Mean ± SD

346 ± 62

339 ± 74

0.0010

346 ± 62

343 ± 68

0.3329

 Median [Range]

365 [42–365]

365 [9–365]

 

365 [42–365]

365 [11–365]

 

Total HCRU pre-index, mean visits per patient [SD]

 Hospitalization

0.8 [0.7]

1.1 [0.9]

<.0001

0.8 [0.7]

0.9 [0.7]

0.0183

 ER visit

0.7 [1.2]

0.8 [1.5]

0.3055

0.7 [1.3]

0.7 [1.1]

0.0603

 Physician office visit

12.4 [9.6]

12.3 [10.3]

0.7100

12.4 [9.7]

11.6 [9.2]

0.0293

 Outpatient visit

5.7 [6.8]

7.3 [14.0]

<.0001

5.7 [6.8]

6.1 [11.6]

0.3758

  1. SD standard deviation, HCRU Healthcare Resource Utilization, ER emergency room