| Baseline | Week 13 | Week 25 | Week 37 | Week 49 | Week 61 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EQ-5D dimensions | ENZA (n = 857), % | PBO (n = 826), % | P value | ENZA (n = 809), % | PBO (n = 624), % | P value | ENZA (n = 746), % | PBO (n = 367), % | P value | ENZA (n = 671), % | PBO (n = 267), % | P value | ENZA (n = 610), % | PBO (n = 176), % | P value | ENZA (n = 523), % | PBO (n = 117), % | P value |
Mobility | ||||||||||||||||||
 Level 1 | 74.9% | 74.7% | 0.5940 | 74.7% | 71.3% | 0.3197 | 73.7% | 70.8% | 0.5823 | 70.4% | 70.3% | 0.8183 | 66.7% | 30.9% | 0.6454 | 68.5% | 71.8% | 0.7640 |
 Level 2 or 3 | 25.1% | 25.3% |  | 25.4% | 28.8% |  | 26.3% | 29.1% |  | 29.7% | 29.7% |  | 33.3% | 69.1% |  | 31.6% | 28.3% |  |
Self-care | ||||||||||||||||||
 Level 1 | 94.9% | 93.8% | 0.1726 | 93.9% | 92.0% | 0.2253 | 94.0% | 90.6% | 0.1034 | 92.4% | 91.7% | 0.2849 | 92.3% | 92.0% | 0.9186 | 6.9% | 10.2% | 0.0619 |
 Level 2 or 3 | 5.1% | 6.2% |  | 6.1% | 8.0% |  | 6.0% | 9.3% |  | 7.7% | 8.3% |  | 7.7% | 8.0% |  | 93.1% | 89.7% |  |
Usual Activities | ||||||||||||||||||
 Level 1 | 80.1% | 80.5% | 0.9685 | 74.9% | 69.3% | 0.0675 | 77.9% | 71.8% | 0.0262 | 76.2% | 76.7% | 0.3589 | 70.8% | 71.8% | 0.9266 | 72.7% | 69.8% | 0.6346 |
 Level 2 or 3 | 20.0% | 19.5% |  | 25.1% | 30.6% |  | 22.1% | 28.2% |  | 23.9% | 23.4% |  | 29.3% | 28.2% |  | 27.31% | 30.2% |  |
Pain/Discomfort | ||||||||||||||||||
 Level 1 | 55.8% | 58.5% | 0.4623 | 56.0% | 47.8% | 0.0051 | 59.8% | 50.7% | 0.0163 | 56.4% | 47.6% | 0.0475 | 52.6% | 52.8% | 0.6281 | 52.4% | 53.9% | 0.4483 |
 Level 2 or 3 | 44.3% | 41.5% |  | 44.1% | 52.2% |  | 40.3% | 49.4% |  | 43.5% | 52.5% |  | 47.5% | 47.1% |  | 47.6% | 46.2% |  |
Anxiety/Depression | ||||||||||||||||||
 Level 1 | 75.0% | 72.9% | 0.0690 | 74.4% | 67.6% | 0.0060 | 76.3% | 71.0% | 0.1610 | 75.9% | 72.9% | 0.5023 | 74.0% | 68.8% | 0.1762 | 70.8% | 71.8% | 0.7396 |
 Level 2 or 3 | 25.0% | 27.2% |  | 25.6% | 32.4% |  | 23.8% | 29.1% |  | 24.1% | 27.0% |  | 26.0% | 31.3% |  | 29.2% | 28.2% |  |