Sensitivity of alternative measures of functioning and wellbeing for adults with sickle cell disease: comparison of PROMIS® to ASCQ-Me℠

Table 5 Comparison of unique variance in SCD severity explained by ASCQ-Me and PROMIS measures

Model^a		Type III test statistics
Model^a		F	P^b
ASCQ-Me & PROMIS measures on pain
I	ASCQ-Me Pain Impact^d	10.78	<0.0011
I	PROMIS Pain Impact	3.15	0.0766
II	ASCQ-Me Pain Impact^d	13.15	0.0003
II	PROMIS Pain Behavior	5.72	0.0172
III	PROMIS Pain Impact^d	33.96	<0.0001
III	ASCQ-Me Pain Episode Frequency	1.16	0.2820
IV	PROMIS Pain Impact^d	40.93	<0.0001
IV	ASCQ-Me Pain Episode Severity	5.27	0.0221
V	PROMIS Pain Behavior^d	33.07	<0.0001
V	ASCQ-Me Pain Episode Frequency	0.92	0.3381
VI	PROMIS Pain Behavior^d	39.63	<0.0001
VI	ASCQ-Me Pain Episode Severity	5.75	0.0169
ASCQ-Me & PROMIS measures of similar health domains
I	ASCQ-Me Stiffness Impact^d	27.40	<0.0001
I	PROMIS Physical Functioning^d	6.92	0.0088
II	ASCQ-Me Social Impact^d	8.17	0.0045
II	PROMIS Satisfaction with Social Roles^d	5.63	0.0181
III	ASCQ-Me Social Impact^d	17.07	<0.0001
III	PROMIS Satisfaction with Social Discretionary Activities	0.84	0.3594
IV	ASCQ-Me Emotional Impact^d	6.94	0.0087
IV	PROMIS Depression	1.50	0.2214
V	ASCQ-Me Emotional Impact^d	13.10	0.0003
V	PROMIS Anxiety	0.04	0.8386
VI	ASCQ-Me Sleep Impact^d	7.84	0.0053
VI	PROMIS Sleep Disturbance	0.25	0.6194
VII	ASCQ-Me Sleep Impact^d	14.24	0.0002
VII	PROMIS Sleep Impairment	1.22	0.2694

^aAll regression models controlled for gender, age, and SCD genotype
^bThe criterion for significance was set at α = 0.05/3 = 0.0166 to control for the family-wise error rate given that the same measure is involved in three or fewer tests (e.g. PROMIS Pain Impact and Pain Behavior are involved in three tests)
^cThe criterion for significance was set at α = 0.05/2 = 0.025 to control for the family-wise error rate given that the same measure is involved in two or fewer tests (e.g. ASCQ-Me Social, Emotional and Sleep impact are involved in two tests)
^dStatistically significant unique variance associated with SCD severity after correction for multiple comparisons

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