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Table 2 Median (IQR) SF-36 Physical and Mental Component Summary scores by respondent characteristic (n = 108)

From: Predictors of quality of life among adolescents and young adults with a bleeding disorder

Characteristic

SF-36 PCS

p-value

SF-36 MCS

p-value

Age

 

0.03

 

0.04

 13–17

86.3 (64.8, 95.7)

 

79.5 (64.6, 85.7)

 

 18–25

75.1 (59.0, 87.1)

 

73.4 (58.6, 78.9)

 

Gender

 

0.12

 

0.10

 Male

83.0 (59.0, 94.5)

 

76.8 (59.6, 85.7)

 

 Female

78.9 (64.8, 86.0)

 

71.4 (64.6, 76.4)

 

Race

 

0.02

 

0.94

 White

83.6 (65.7, 94.3)

 

75.9 (59.6, 84.3)

 

 Non-whitea

62.6 (48.3, 84.8)

 

74.3 (64.6, 85.7)

 

Ethnicity

 

0.18

 

0.73

 Hispanic

71.9 (59.3, 81.5)

 

77.0 (67.0, 82.1)

 

 Non-Hispanic

83.0 (61.1, 94.2)

 

75.2 (59.6, 84.8)

 

Health insuranceb

 

0.13

 

0.21

 Medicaid or VA onlyc

79.4 (56.0, 86.4)

 

75.9 (64.6, 85.7)

 

 Commercial only

86.2 (65.0, 95.7)

 

78.8 (65.0, 84.3)

 

 Both

71.0 (60.8, 77.7)

 

72.9 (59.3, 81.3)

 

 Insured, type unknown

83.7 (69.6, 91.8)

 

64.3 (54.6, 86.3)

 

 Uninsured

63.0 (41.4, 90.5)

 

61.8 (42.9, 69/3)

 

Mother’s education level

 

0.19

 

0.71

 Bachelor’s degree or higher

86.1 (65.7, 95.5)

 

75.7 (60.4, 85.4)

 

 Less than Bachelor’s degree

80.1 (58.1, 91.0)

 

75.5 (59.6, 84.3)

 

Father’s education level

 

0.10

 

0.46

 Bachelor’s degree or higher

88.3 (67.4, 95.5)

 

76.4 (58.6, 87.1)

 

 Less than Bachelor’s degree

79.8 (58.1, 91.0)

 

75.4 (60.4, 82.9)

 

Bleeding disorder

 

0.78

 

0.34

 Hemophilia A

81.2 (58.1, 94.5)

 

76.4 (59.3, 85.7)

 

 Hemophilia B

81.7 (73.2, 88.5)

 

76.1 (65.0, 81.8)

 

 von Willebrand

80.5 (64.8, 86.2)

 

70.0 (64.6, 76.4)

 

Severity

 

0.98

 

0.37

 Mild

81.6 (65.0, 91.7)

 

73.2 (61.8, 78.6)

 

 Moderate

86.0 (64.0, 88.6)

 

75.4 (60.4, 87.1)

 

 Severe

79.8 (58.1, 94.3)

 

76.4 (59.6, 85.7)

 

Inhibitor development

 

<0.01

 

0.16

 Ever

69.0 (45.0, 85.2)

 

73.4 (56.8, 83.9)

 

 Never

86.1 (67.9, 94.5)

 

78.2 (64.6, 86.4)

 

Treatment regimen

 

0.99

 

0.13

 On-demand

81.9 (66.2, 91.7)

 

72.9 (59.3, 78.9)

 

 Prophylaxis

81.2 (58.1, 94.5)

 

77.1 (60.4, 85.7)

 

Chronic paind

 

<0.0001

 

0.01

 None to mild

87.1 (75.5, 95.5)

 

77.1 (64.6, 86.8)

 

 Moderate to severe

59.0 (45.0, 74.5)

 

72.9 (56.8, 78.8)

 

Clotting factor adherencee

 

0.24

 

0.04

 Adherent

82.6 (64.8, 95.5)

 

76.4 (64.6, 84.3)

 

 Non-adherent

79.0 (55.5, 90.5)

 

68.2 (48.6, 78.6)

 
  1. aMost (73%) of non-white respondents were black or African American, 14% were mixed race, 9% were Asian, and 5% were American Indian or Alaskan Native
  2. b n = 78, two participants answered ‘Don’t Know’ to whether or not they had health insurance and were not included
  3. cOnly two participants had VA only insurance, the others had Medicaid only
  4. dChronic Pain was measured using the revised Faces Pain Scale (FPS-R) and was dichotomized as FPS-R < 4 (i.e., ‘mild’ or ‘no pain) and FPS-R ≥ 4 (i.e., ‘moderate’ to ‘worst pain possible’)
  5. eAdherence was assessed using the Validated Hemophilia Regimen Treatment Adherence Scale (VERITAS)-Pro and VERITAS-PRN for prophylactic and on-demand participants, respectively. The cutoff for non-adherent prophylactic participants was a total VERITAS-Pro score ≥57, as established previously by Duncan and colleagues [25]. This value was chosen because the VERITAS-Pro cutoff was approximately the 75th percentile of all responses
  6. SF-36 36-Item Short Form Health Survey, MCS Mental Component Summary, PCS Physical Component Summary
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Health and Quality of Life Outcomes

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