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Table 6 Saturated multivariate repeated measures mixed model assessing independent predictors of the EQ-5D summary score and EQ-5D VAS

From: Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies

  EQ-5D Item
EQ-5D overall summary scores EQ-5D VAS
Predictor Estimatea SD 95% CI for estimate p-value Estimatea SD 95% CI for estimate p-value
Work Time Loss Category
 Work Time Lossb vs. No Work Time Loss −0.102 0.014 −0.129, −0.074 <0.001 −6.511 1.109 −8.687, −4.336 <0.001
Time from HZ onset - categorical
 Prevalent vs. incident −0.016 0.019 −0.052, 0.020 0.387 −0.871 1.754 −4.320, 2.578 0.620
Worst Pain Categoryc
 Moderate vs. mild −0.083 0.014 −0.109, −0.056 <0.001 −8.761 1.079 −10.88, −6.643 <0.001
 Severe vs. mild −0.290 0.018 −0.326, −0.254 <0.001 −14.40 1.445 −17.23, −11.56 <0.001
Severity of rash (number of lesions)
 Mild (1–20) vs. no rash 0.044 0.021 0.002, 0.086 0.042 4.150 2.128 0.035, 8.334 0.052
 Moderate (21–50) vs. no rash 0.035 0.028 −0.019, 0.090 0.206 3.755 2.667 −1.489, 8.999 0.160
 Severe (>50) vs. no rash 0.070 0.029 0.012, 0.128 0.017 4.621 2.865 −1.014, 10.255 0.108
Country category (income)d
 High vs. Upper Middle −0.027 0.033 −0.091, 0.038 0.413 −8.532 2.902 −14.24, −2.828 0.003
Geographic regione
 Latin America vs. Asia 0.021 0.032 −0.042, 0.083 0.513 −2.793 2.839 −8.374, 2.788 0.326
 North America vs. Asia 0.005 0.024 −0.043, 0.052 0.851 1.428 2.253 −3.001, 5.856 0.527
Presence of complications of HZ
 Yes vs. no - - - - −4.509 1.654 −7.761, −1.257 0.007
  1. SD standard deviation, CI confidence interval, VAS visual analogue scale, WPQ Work and Productivity Questionnaire
  2. aThe estimate is the relative effect of the predictor on EQ-5D scores compared to the reference group
  3. b Patients with Work Time Loss were defined as those who reported missing work due to their shingles episode (entire day or part of a day) at baseline, or at any of the follow-up visits (Visits 2–10) as assessed by the WPQ
  4. c Worst pain categories are based on the ZBPI “worst pain in the last 24 h” scores: mild worst pain = ZBPI scores 0- ≤ 3; moderate worst pain = ZBPI scores 4- ≤ 7; severe worst pain = ZBPI score ≥8
  5. d Country income classifications are based on the 2016 World Bank economic definitions [22]. High Income= Canada, South Korea, Taiwan, Argentina; Upper Middle Income= Brazil, Costa Rica, Mexico, Thailand
  6. e Asia = Taiwan, Thailand, South Korea; Latin America = Argentina, Brazil, Costa Rica; Mexico; North America = Canada