Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies

Table 6 Saturated multivariate repeated measures mixed model assessing independent predictors of the EQ-5D summary score and EQ-5D VAS

	EQ-5D Item
	EQ-5D overall summary scores				EQ-5D VAS
Predictor	Estimate^a	SD	95% CI for estimate	p-value	Estimate^a	SD	95% CI for estimate	p-value
Work Time Loss Category
Work Time Loss^b vs. No Work Time Loss	−0.102	0.014	−0.129, −0.074	<0.001	−6.511	1.109	−8.687, −4.336	<0.001
Time from HZ onset - categorical
Prevalent vs. incident	−0.016	0.019	−0.052, 0.020	0.387	−0.871	1.754	−4.320, 2.578	0.620
Worst Pain Category^c
Moderate vs. mild	−0.083	0.014	−0.109, −0.056	<0.001	−8.761	1.079	−10.88, −6.643	<0.001
Severe vs. mild	−0.290	0.018	−0.326, −0.254	<0.001	−14.40	1.445	−17.23, −11.56	<0.001
Severity of rash (number of lesions)
Mild (1–20) vs. no rash	0.044	0.021	0.002, 0.086	0.042	4.150	2.128	0.035, 8.334	0.052
Moderate (21–50) vs. no rash	0.035	0.028	−0.019, 0.090	0.206	3.755	2.667	−1.489, 8.999	0.160
Severe (>50) vs. no rash	0.070	0.029	0.012, 0.128	0.017	4.621	2.865	−1.014, 10.255	0.108
Country category (income)^d
High vs. Upper Middle	−0.027	0.033	−0.091, 0.038	0.413	−8.532	2.902	−14.24, −2.828	0.003
Geographic region^e
Latin America vs. Asia	0.021	0.032	−0.042, 0.083	0.513	−2.793	2.839	−8.374, 2.788	0.326
North America vs. Asia	0.005	0.024	−0.043, 0.052	0.851	1.428	2.253	−3.001, 5.856	0.527
Presence of complications of HZ
Yes vs. no	-	-	-	-	−4.509	1.654	−7.761, −1.257	0.007

SD standard deviation, CI confidence interval, VAS visual analogue scale, WPQ Work and Productivity Questionnaire
^aThe estimate is the relative effect of the predictor on EQ-5D scores compared to the reference group
^b Patients with Work Time Loss were defined as those who reported missing work due to their shingles episode (entire day or part of a day) at baseline, or at any of the follow-up visits (Visits 2–10) as assessed by the WPQ
^c Worst pain categories are based on the ZBPI “worst pain in the last 24 h” scores: mild worst pain = ZBPI scores 0- ≤ 3; moderate worst pain = ZBPI scores 4- ≤ 7; severe worst pain = ZBPI score ≥8
^d Country income classifications are based on the 2016 World Bank economic definitions [22]. High Income= Canada, South Korea, Taiwan, Argentina; Upper Middle Income= Brazil, Costa Rica, Mexico, Thailand
^e Asia = Taiwan, Thailand, South Korea; Latin America = Argentina, Brazil, Costa Rica; Mexico; North America = Canada

ISSN: 1477-7525