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Table 7 MID for QLQ-C30 and QLQ-BR23 questionnaires after 3 and 6 months compared to a threshold of 5 points

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

  After 3 months After 6 months
Observed changes Adjusted changes Observed changes Adjusted changes
QLQ-C30
 Global Health Status 16 12a 0.5 8a
 Physical functioning 12 12a 0.4 9a
 Role functioning 26 19a 2 18a
 Cognitive functioning 5 11a 1 10a
 Social functioning 20 15a 1 10a
 Emotional functioning 3.5 6a 0.5 6a
 Fatigue 27 23a 0.2 20a
 Pain 14 9a 2 17a
 Dyspnea 9 11a 4 8a
 Insomnia 6 8a 4 15a
 Financial difficulties 10 8a 3 5a
 Appetite loss 10 11a 10 4
 Constipation 15 10a 1 3
 Nausea and vomiting 9 8a 3 1
QLQ-BR23
 Body image 20 15a 0.4 11a
 Sexual functioning 7 7a 0.4 11a
 Systemic therapy side effects 19 20a 3 10a
 Breast symptoms 14 18a 4 6a
 Arm symptoms 8 9a 0.6 11a
 Sexual enjoyment 14 12a 13 15a
 Future perspectives 7 9a 3 0.7
  1. a indicates that the MID stayed or became greater than 5 points when the response shift effect was taken into account