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Table 7 MID for QLQ-C30 and QLQ-BR23 questionnaires after 3 and 6 months compared to a threshold of 5 points

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

 

After 3 months

After 6 months

Observed changes

Adjusted changes

Observed changes

Adjusted changes

QLQ-C30

 Global Health Status

16

12a

0.5

8a

 Physical functioning

12

12a

0.4

9a

 Role functioning

26

19a

2

18a

 Cognitive functioning

5

11a

1

10a

 Social functioning

20

15a

1

10a

 Emotional functioning

3.5

6a

0.5

6a

 Fatigue

27

23a

0.2

20a

 Pain

14

9a

2

17a

 Dyspnea

9

11a

4

8a

 Insomnia

6

8a

4

15a

 Financial difficulties

10

8a

3

5a

 Appetite loss

10

11a

10

4

 Constipation

15

10a

1

3

 Nausea and vomiting

9

8a

3

1

QLQ-BR23

 Body image

20

15a

0.4

11a

 Sexual functioning

7

7a

0.4

11a

 Systemic therapy side effects

19

20a

3

10a

 Breast symptoms

14

18a

4

6a

 Arm symptoms

8

9a

0.6

11a

 Sexual enjoyment

14

12a

13

15a

 Future perspectives

7

9a

3

0.7

  1. a indicates that the MID stayed or became greater than 5 points when the response shift effect was taken into account