| Deterioration of HRQOL | Improvement of HRQOL | ||
---|---|---|---|---|
Observed changes | Adjusted changes | Observed changes | Adjusted changes | |
QLQ-BR23 QLQ - C30 | ||||
 After 3 months | 5–26 | 8–19 | 0.3–10 | 0.6–4 |
 After 6 months | 0.5–10 | 4–18 | 0.8–7 | 0–7 |
 After 3 months | 7–20 | 7–18 | 2–15 | 0–7 |
 After 6 months | 0.4–4 | 6–11 | 0.7–2 | 0–4 |