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Table 5 Observed and adjusted changes of the QLQ–BR23 questionnaire after three and six months

From: Impact of the occurrence of a response shift on the determination of the minimal important difference in a health-related quality of life score over time

  After 3 months After 6 months
  Between T0 and T1 Between T1 and T2
QLQ-BR23   Observed changes Adjusted changes   Observed changes Adjusted changes
(post-test - pre-test) (post-test - then-test) (post-test - pre-test) (post-test - then-test)
  N Mean (SD) 95% CI Mean (SD) 95% CI N Mean (SD) 95% CI Mean (SD) 95% CI
Body image 232      232     
 Little worse 70 −20.44 (27.41) (−26, −15) −15.40 (25.02) (−20, −10) 47 0.41 (16.58) (−4, 4) −10.76 (22.82) (−16, −5)
 No change 41 −7.32 (15.16) (−11, −3) −4.07 (15.60) (−8, 0) 46 2.72 (10.1) (0, 5) −0.91 (12.82) (−4, 2)
 Little better 49 −14.91 (24.41) (−21, −9) −4.93 (18.31) (−9, −1) 65 1.28 (22.93) (−3, 6) −1.45 (20.88) (−6, 3)
Sexual functioning 198      198     
 Little worse 56 6.85 (20.79) (2, 11) 7.44 (21.06) (3, 12) 56 −0.44 (12.55) (−4, 3) 10.53 (17.93) (6, 15)
 No change 34 3.92 (22.87) (−3, 11) 5.88 (22.80) (−1, 13) 34 2.03 (16.33) (−2, 6) 2.44 (16.48) (−2, 7)
 Little better 43 1.94 (15.94) (−2, 6) 0 (10.91) (−3, 3) 43 −0.89 (18.1) (−5, 3) 0 (17.70) (−4, 4)
Sexual enjoyment 74      74     
 Little worse 23 14.49 (19.66) (7, 22) 11.59 (19.09) (5, 18) 23 12.50 (29.5) (0, 25) 14.58 (20.97) (5, 24)
 No change 16 10.42 (33.82) (−4, 25) 4.17 (29.50) (−9, 17) 16 1.45 (21.27) (−6, 9) 2.90 (28.27) (−7, 13)
 Little better 11 12.12 (22.47) (0, 24) 9.09 (21.56) (−3, 21) 11 −2.08 (22.67) (−12, 8) 0 (21.08) (−9, 9)
Future perspectives 236      236     
 Little worse 68 7.35 (32.5) (1, 14) −8.82 (30.81) (−15, −3) 68 3.47 (30.16) (−4, 11) −0.69 (24.30) (−7, 5)
 No change 43 20.93 (32.55) (13, 29) 7.75 (26.06) (1, 14) 43 0 (23.57) (−6, 6) 4.76 (30.43) (−3, 12)
 Little better 48 10.42 (30.1) (3, 18) 3.47 (24.06) (−2, 9) 48 1.06 (25.38) (−4, 6) 8.47 (23.92) (3, 13)
Systemic therapy side effects 252      252     
 Little worse 72 18.83 (21.51) (15, 23) 19.79 (18.60) (16, 23) 72 −3.49 (18.26) (−8, 1) 10.27 (18.90) (6, 15)
 No change 45 4.41 (15.02) (1, 8) 3.84 (14.03) (0, 7) 45 0.23 (10.2) (−2, 3) 2.45 (7.89) (1, 4)
 Little better 54 6.02 (13.64) (3, 9) 6.02 (12.35) (3, 9) 54 −4.19 (15.12) (−7, −1) 3.94 (19.39) (0, 8)
Breast symptoms 212      212     
 Little worse 57 14.08 (27.69) (8, 2) 18.08 (22.21) (13, 23) 57 −4.31 (16.81) (−8, 0) 6.44 (18.26) (2, 11)
 No change 36 10.34 (20.43) (5, 16) 9.72 (21.59) (4, 16) 36 −3.57 (13.35) (−7, 0) 3.77 (14.28) (0, 7)
 Little better 53 16.61 (21.1) (12, 21) 7.13 (18.87) (3, 11) 53 −2.21 (20.17) (−7, 2) 3.63 (20.65) (−1, 8)
Arm symptoms 235      235     
 Little worse 67 7.88 (17.6) (4, 11) 8.54 (19.28) (5, 12) 67 0.58 (18.27) (−4, 5) 10.76 (19.53) (6, 15)
 No change 41 3.39 (13.54) (0, 7) 4.74 (14.14) (1, 8) 41 1.89 (13.82) (−1, 5) 5.89 (14.65) (2, 9)
 Little better 55 4.55 (17.51) (1, 8) 1.41 (13.83) (−2, 5) 55 0.69 (13.98) (−2, 4) 0.69 (16.93) (−3, 4)
  1. Observed changes Post-test – Pre-test; adjusted changes: Post-test – Then-test
  2. SD standard deviation, CI confidence interval