Author, year | HRQoL stated as prim./sec. aima | A priori hypothesis | Instrument rational | Instrument validationb | Cancer-specific instrument | Instrument administration | (Baseline) compliance | Timing of assessments | Missing data reported | Statistical methods for missing data | Power or effect sizes (HRQoL) | Presentation of results adequatec | Clinical significance addressed | HRQoL results discussed |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Randomised controlled trials | ||||||||||||||
Arnold et al., 2005 [52] | - | - | + | + | + | - | + | + | + | - | - | - | - | + |
Bajetta et al., 2006 [53] | - | - | - | + | + | + | - | + | + | + | - | - | - | + |
Caplin et al., 2014 [42] (CLARINET) | + | - | - | + | + | - | - | + | + | + | - | + | - | - |
Jacobsen & Hanssen, 1995 [54] | + | - | - | + | -d | - | + | + | + | - | - | - | + | + |
Meyer et al., 2014 [55] | + | - | - | + | + | - | + | + | + | - | - | - | - | - |
Raymond et al., 2011 [56] | - | - | - | + | + | + | - | + | + | - | - | - | + | + |
Rinke et al., 2009 [57] (PROMID) | - | - | - | + | + | - | + | + | - | - | - | - | - | - |
Yao et al., 2016 [45] (RADIANT-4) | - | - | + | + | + | + | + | + | - | + | - | n.r. | + | n.r. |
Phase II studies | ||||||||||||||
Bodei et al., 2011 [58] | - | - | - | + | + | - | - | + | - | - | - | - | - | + |
Bushnell et al., 2010 [59] | - | - | - | + | - | - | + | + | + | - | - | - | - | - |
Claringbold et al., 2011 [60] | - | - | - | + | + | - | - | + | + | - | - | - | - | + |
Cwikla et al., 2010 [61] | - | - | - | + | + | + | - | + | + | - | - | - | - | - |
Delpassand et al., 2014 [62] | - | - | - | + | + | - | - | + | + | - | - | - | - | - |
Ducreux et al., 2014 [43]; Mitry et al., 2014 [44] (BETTER) | + | - | - | + | + | - | - | + | + | - | - | - | - | - |
Frilling et al., 2006 [63] | - | - | - | + | - | - | - | + | + | - | - | - | - | - |
Khan et al., 2011 [64] | N/A | - | + | + | + | + | + | + | + | - | - | - | + | + |
Korse et al., 2009 [65] | N/A | - | + | + | +d | - | - | - | + | - | - | - | - | N/A |
Kulke et al., 2008 [66] | - | - | - | + | - | + | - | + | + | - | - | - | - | + |
Kvols et al., 2012 [67] | - | - | - | + | + | - | - | + | + | - | - | - | - | + |
Martin-Richard et al., 2013 [68] | + | - | - | + | + | - | - | + | - | - | - | + | - | - |
Ruszniewski et al., 2004 [69] | - | - | - | + | + | - | + | + | + | - | - | - | - | + |
Wymenga et al., 1999 [70] | - | - | - | + | + | - | - | + | - | + | - | + | - | + |
Zuetenhorst et al., 2004 [71] | - | + | - | + | +d | - | - | + | + | - | - | - | - | + |
Prospective studies | ||||||||||||||
Fröjd et al., 2007 [72]; Fröjd et al., 2009 [73] | N/A | N/A | - | + | +d | + | + | + | + | + | - | + | + | N/A |
Haugland et al., 2013 [74] | N/A | - | - | + | - | + | + | + | + | + | + | + | - | N/A |
Kalinowski et al., 2009 [75] | - | - | + | + | + | - | - | + | - | - | - | - | - | + |
Kwekkeboom et al., 2003 [76] | - | - | - | + | + | + | - | + | + | - | - | - | - | + |
Larsson & Janson, 2008 [77] | N/A | N/A | + | + | + | - | - | + | + | - | - | + | + | N/A |
Larsson et al., 2001 [78] | N/A | - | - | + | +d | + | + | + | + | - | - | + | + | N/A |
O’Toole et al., 2000 [79] | - | + | - | + | -d | + | - | + | - | - | - | + | - | + |
Pasieka et al., 2004 [80] | - | - | - | - | - | + | + | + | + | - | - | - | + | + |
Spolverato et al., 2015 [81] | N/A | + | + | - | + | + | + | + | + | - | - | - | - | N/A |
Teunissen et al., 2004 [82] | N/A | N/A | + | + | + | + | - | + | + | + | - | + | + | N/A |
Cross-sectional studies | ||||||||||||||
Beaumont et al., 2012 [83]; | N/A | N/A | - | + | - | + | + | N/A | + | - | + | + | + | N/A |
Pearman et al., 2016 [84] | - | |||||||||||||
Gelhorn et al., 2016 [85] | - | N/A | - | + | + | + | + | N/A | + | - | N/A | - | + | + |
Haugland et al., 2009 [86] | N/A | N/A | + | + | - | + | + | N/A | + | - | + | + | + | N/A |
Haugland et al., 2016 [87] | N/A | + | - | + | - | + | + | N/A | + | + | - | - | - | N/A |
Larsson et al., 1998 [88] | N/A | N/A | + | + | +d | + | + | N/A | + | - | N/A | - | - | N/A |
Larsson, Sjöden et al., 1999 [89] | N/A | N/A | + | + | + | + | - | N/A | + | - | N/A | + | + | N/A |
Larsson, von Essen et al., 1999 [90] | N/A | N/A | + | + | +d | + | + | N/A | + | - | N/A | + | + | N/A |
Larsson et al., 2003 [91] | N/A | N/A | N/A | N/A | N/A | + | - | N/A | + | N/A | N/A | N/A | N/A | N/A |
Larsson et al., 2007 [92] | N/A | N/A | + | + | +d | + | + | N/A | + | - | N/A | + | - | N/A |
Petzel et al., 2012 [93] | N/A | + | + | + | + | + | - | N/A | + | + | N/A | + | - | N/A |
Pezzilli et al., 2009 [94] | N/A | - | - | + | - | + | + | N/A | + | - | - | - | - | N/A |
Pezzilli et al., 2010 [95] | N/A | - | - | + | - | + | - | N/A | - | - | - | - | - | N/A |
Ruszniewski et al., 2016 [96] (SYMNET) | - | N/A | - | + | + | + | - | N/A | - | + | + | - | - | + |
van der Horst-Schrivers et al., 2009 [97] | N/A | N/A | - | + | + | + | + | N/A | - | - | - | + | - | N/A |
von Essen et al., 2002 [98] | N/A | N/A | - | + | + | + | + | N/A | + | - | - | - | - | N/A |