Skip to main content

Table 5 Impact of clinical events on EQ-5DIndex among AVR patients accounting for time-to-death

From: Quality of life among elderly patients undergoing transcatheter or surgical aortic valve replacement– a model-based longitudinal data analysis

  Time-to-death adjustment (six months) Exclusion of cases of mortality (six months prior to death) EQ-5DIndex = 0 in month of death
  (1) (2) (3) (4) (5) (6)
  EQ-5DIndex EQ-5DIndex EQ-5DIndex EQ-5DIndex EQ-5DIndex EQ-5DIndex
Value at baseline 0.348*** 0.346*** 0.333*** 0.331*** 0.333*** 0.331***
ASB life threatening/disabling −0.0593 −0.140* 0.0356 −0.0497 −0.0599 −0.121
…at the second follow-up after event   −0.145*   −0.155*   −0.0993
…at the third follow-up after event   −0.163**   −0.0950   −0.145*
NASB life threatening/disabling −0.449*** −0.493*** −0.457*** −0.508*** −0.448*** −0.465***
…at the second follow-up after event   −0.114   −0.140   −0.101
…at the third follow-up after event   0.103   0.0936   0.109
Stroke / TIA −0.147* −0.206** −0.145* −0.210** −0.147* −0.199*
…at the second follow-up after event   −0.123   −0.146*   −0.121
…at the third follow-up after event   −0.0319   −0.0286   −0.0307
AKIN 2 −0.167* −0.226** −0.267** −0.270** −0.169* −0.272**
…at the second follow-up after event   −0.142   −0.0428   −0.195*
…at the third follow-up after event   0.0657   0.0150   0.0508
AKIN 3 −0.173** −0.186** −0.235** −0.293*** −0.381*** −0.418***
…at the second follow-up after event   −0.113   −0.177*   −0.235**
…at the third follow-up after event   −0.00684   −0.0338   −0.0939
Other complications 0.00548 0.00571 0.0134 0.0140 0.00464 0.00368
Last follow-up before death −0.493*** −0.487***     
Second last follow-up before death −0.275*** −0.272***     
Third from last follow-up before death −0.210*** −0.217***     
Fourth from last follow-up before death −0.180*** −0.189***     
Fifth from last follow-up before death −0.154*** −0.166***     
Sixth from last follow-up before death −0.108** −0.116**     
Overall trend −0.00161 −0.00222** −0.00195* −0.00249** −0.00322*** −0.00386***
Month 1 post-discharge −0.0230 −0.0283 −0.0256 −0.0301 −0.0163 −0.0218
Constant 0.529*** 0.543*** 0.548*** 0.559*** 0.508*** 0.523***
N 2212 2212 2102 2102 2250 2250
  1. * p < 0.05, ** p < 0.01, *** p < 0.001
  2. The EQ-5DIndex is a continuous variable between 0 and 1 (0 = worst state, 1 = best state). ASB access site bleeding, NASB non-Access Site Bleeding, VASC vascular complication, AKIN acute kidney injury. Please note that we also increased these time lags up to 6 months after complications but found no additional effects