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Table 5 Impact of clinical events on EQ-5DIndex among AVR patients accounting for time-to-death

From: Quality of life among elderly patients undergoing transcatheter or surgical aortic valve replacement– a model-based longitudinal data analysis

 

Time-to-death adjustment (six months)

Exclusion of cases of mortality (six months prior to death)

EQ-5DIndex = 0 in month of death

 

(1)

(2)

(3)

(4)

(5)

(6)

 

EQ-5DIndex

EQ-5DIndex

EQ-5DIndex

EQ-5DIndex

EQ-5DIndex

EQ-5DIndex

Value at baseline

0.348***

0.346***

0.333***

0.331***

0.333***

0.331***

ASB life threatening/disabling

−0.0593

−0.140*

0.0356

−0.0497

−0.0599

−0.121

…at the second follow-up after event

 

−0.145*

 

−0.155*

 

−0.0993

…at the third follow-up after event

 

−0.163**

 

−0.0950

 

−0.145*

NASB life threatening/disabling

−0.449***

−0.493***

−0.457***

−0.508***

−0.448***

−0.465***

…at the second follow-up after event

 

−0.114

 

−0.140

 

−0.101

…at the third follow-up after event

 

0.103

 

0.0936

 

0.109

Stroke / TIA

−0.147*

−0.206**

−0.145*

−0.210**

−0.147*

−0.199*

…at the second follow-up after event

 

−0.123

 

−0.146*

 

−0.121

…at the third follow-up after event

 

−0.0319

 

−0.0286

 

−0.0307

AKIN 2

−0.167*

−0.226**

−0.267**

−0.270**

−0.169*

−0.272**

…at the second follow-up after event

 

−0.142

 

−0.0428

 

−0.195*

…at the third follow-up after event

 

0.0657

 

0.0150

 

0.0508

AKIN 3

−0.173**

−0.186**

−0.235**

−0.293***

−0.381***

−0.418***

…at the second follow-up after event

 

−0.113

 

−0.177*

 

−0.235**

…at the third follow-up after event

 

−0.00684

 

−0.0338

 

−0.0939

Other complications

0.00548

0.00571

0.0134

0.0140

0.00464

0.00368

Last follow-up before death

−0.493***

−0.487***

    

Second last follow-up before death

−0.275***

−0.272***

    

Third from last follow-up before death

−0.210***

−0.217***

    

Fourth from last follow-up before death

−0.180***

−0.189***

    

Fifth from last follow-up before death

−0.154***

−0.166***

    

Sixth from last follow-up before death

−0.108**

−0.116**

    

Overall trend

−0.00161

−0.00222**

−0.00195*

−0.00249**

−0.00322***

−0.00386***

Month 1 post-discharge

−0.0230

−0.0283

−0.0256

−0.0301

−0.0163

−0.0218

Constant

0.529***

0.543***

0.548***

0.559***

0.508***

0.523***

N

2212

2212

2102

2102

2250

2250

  1. * p < 0.05, ** p < 0.01, *** p < 0.001
  2. The EQ-5DIndex is a continuous variable between 0 and 1 (0 = worst state, 1 = best state). ASB access site bleeding, NASB non-Access Site Bleeding, VASC vascular complication, AKIN acute kidney injury. Please note that we also increased these time lags up to 6 months after complications but found no additional effects