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Table 4 Impact of clinical events on QoL measures among TAVR and SAVR patients

From: Quality of life among elderly patients undergoing transcatheter or surgical aortic valve replacement– a model-based longitudinal data analysis

 

Quality of life

Heart function

Status of assistance

 

EQ-5DIndex

Five EQ-5D dimensions

   
 

(1)

(2)

(3)

(4)

(5)

(6)

(7)

(8)

(9)

 

EQ-5DIndex

Mobility

Looking after myself

Doing usual activities

Having pain or discomfort

Feeling worried, sad or unhappy

NYHA score

CCS score

Status of assistance

 

Point estimate

Odds ratios from the ordered logistic regression model

Value at baseline

0.350***

14.19***

34.09***

10.96***

1.671*

2.751***

2.457***

1.398***

10.82**

ASB life threatening/disabling

−0.0463

12.68**

0.680

0.199

2.860

0.771

0.123

0.188

0.104

ASB major/minor

0.0985*

0.587

0.499

0.201**

0.182*

0.121*

0.762

0.673

0.342

NASB life threatening/disabling

−0.447***

584.6**

54.93

7.752

0.739

47.86*

1.410

1.591

86.32*

NASB major/minor

−0.0199

1.188

0.688

0.597

1.311

0.573

1.180

0.813

4.088

VASC major/minor

−0.00695

0.282

0.971

2.029

0.833

2.110

1.422

0.660

6.198

Stroke/TIA

−0.161*

8.298**

1.358

4.179

6.661

2.561

0.343

0.380

0.958

AKIN 1

0.0659

1.270

1.104

0.357

0.430

0.742

0.547

0.601

0.718

AKIN 2

−0.158*

1.297

7.126

102.2**

0.814

0.340

81.36*

104.2**

21.79

AKIN 3

−0.177**

15.75***

21.53**

7.419*

2.908

3.495

1.243

1.404

1.955

Arrhythmia

−0.0377

2.393

3.153

1.954

1.817

2.200

3.490

0.234*

1.270

Other complications

0.0330

2.617

0.933

0.457

0.366

0.402

1.380

5.237*

1.057

Last follow-up before death

−0.493***

81.93***

154.9***

48.14**

29.90***

32.98***

2.877

1.335

144.8**

Second last follow-up before death

−0.270***

11.50**

23.04***

5.949

15.13***

11.13***

1.542

1.786

12.95

Third from last follow-up before death

−0.204***

8.142

17.64**

4.509

1.996

3.602

3.855*

1.377

66.29**

Fourth from last follow-up before death

−0.176***

7.797*

11.09**

5.952

2.471

7.750**

1.581

2.016

23.22*

Fifth from last follow-up before death

−0.150***

4.843

13.36**

8.091

1.600

2.446

0.926

1.217

25.23*

Sixth from last follow-up before death

−0.104*

1.800

3.205

2.907

3.803

2.932

1.259

1.081

35.30*

Overall trend

−0.00165

1.085***

1.045

0.966

1.044***

0.983

1.056***

1.020

1.088**

Month 1 post-discharge

−0.0233

1.602

1.433

2.066*

1.465

1.130

1.370

1.599

2.774

Constant

0.528***

        

N

2212

2246

2256

2254

2254

2219

2182

2022

1357

  1. * p < 0.05, ** p < 0.01, *** p < 0.001
  2. The EQ-5DIndex is a continuous variable between 0 and 1 (0 = worst state, 1 = best state). The 5 EQ-5D dimensions as shown in Model (2) to model (6) are order categorical variables (1 = no problems, 2 = some problems, 3 = extreme problems). Canadian Cardiovascular Society (CCS) Angina Grading Scale is an order categorical variable between 1 (angina only during strenuous or prolonged physical activity) and 4 (inability to perform any activity without angina). New York Heart Association (NYHA) Functional Classification is an order categorical variable between 1 (cardiac disease, but no symptoms and no limitation in ordinary physical activity) and 4 (severe limitations, experiences symptoms even while at rest). The current state of assistance is an order categorical variable with 1 (no external help or intra-familial help only), 2 (assisted living and/or home care services) and 3 (short or long-term care or temporal hospitalization). ASB access site bleeding, NASB non-access site bleeding, VASC vascular complication, AKIN acute kidney injury
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Health and Quality of Life Outcomes

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