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Table 3 EORTC-QLQ-C30 scores at baseline and follow-up stratified by cancer diagnosis (yes/no), and the difference between diagnosis groups

From: Health-related quality of life, anxiety and depression in the diagnostic phase of suspected cancer, and the influence of diagnosis

 

Cancer

Not cancer

      
 

Baseline

Follow-up

Difference within groupa

Baseline

Follow-up

Difference within groupa

Differences between groups at baselineb

Differences between groups at follow-upb

Difference between intra difference in groupsb

EORCT

n=125

n=125

p-value

n=549

n=549

p-value

p-value

ES c

p-value

ES c

p-value

ES c

Global Health/QL, mean (SD)

53 (23)

56 (27)

0.19

53 (24)

60 (25)

<0.001

0.95

0.01

0.24

0.13

0.08

0.16

Functional scales, mean (SD)

 Physical functioning

74 (24)

70 (27)

0.42

75 (23)

76 (23)

0.39

0.78

0.06

0.07

0.25

0.28

0.28

 Role functioning

57 (35)

56 (36)

0.64

63 (34)

68 (32)

<0.001

0.10

0.17

<0.001

0.38

0.06

0.22

 Emotional functioning

74 (21)

73 (22)

0.39

70 (24)

75 (24)

<0.001

0.07

0.19

0.13

0.08

<0.001

0.35

 Cognitive functioning

84 (21)

80 (23)

<0.01

79 (24)

79 (22)

0.35

<0.01

0.25

0.59

0.03

0.001

0.33

 Social functioning

82 (26)

77 (30)

0.06

79 (26)

79 (28)

0.44

0.11

0.11

0.62

0.08

0.03

0.22

Symptom scales/items, mean (SD)

 Fatigue

45 (31)

44 (30)

0.86

46 (28)

40 (27)

<0.001

0.47

0.07

0.24

0.13

0.003

0.26

 Nausea and vomiting

10 (17)

11 (19)

0.93

10 (17)

8 (16)

<0.001

0.75

0.01

0.08

0.18

0.08

0.20

 Pain

31 (31)

30 (31)

0.33

35 (32)

32 (31)

<0.01

0.24

0.12

0.37

0.08

0.98

0.04

 Dyspnea

27 (33)

25 (30)

0.52

22 (30)

19 (27)

<0.01

0.12

0.17

0.02

0.24

0.63

0.04

 Insomnia

31 (34)

33 (33)

0.53

34 (35)

32 (33)

0.31

0.39

0.09

0.88

0.01

0.30

0.12

 Appetite loss

33 (38)

32 (36)

0.92

29 (35)

23 (32)

<0.001

0.40

0.10

0.02

0.25

0.07

0.18

 Constipation

15 (28)

19 (30)

0.47

15 (26)

14 (25)

0.32

0.59

0.01

0.12

0.18

0.26

0.19

 Diarrhea

16 (27)

14 (26)

0.57

17 (28)

14 (24)

<0.001

0.65

0.04

0.64

0.01

0.36

0.06

 Financial difficulties

5 (15)

9 (18)

<0.01

9 (24)

11 (25)

0.04

0.07

0.20

0.94

0.09

0.13

0.12

  1. Bold values show statistical differences within and between groups
  2. aWilcoxon signed-rank test
  3. bWilcoxon rank sum test
  4. cEffect size (ES) estimated by Cohen’s d; <0.20 = none, 0.20–0.49 = small, 0.50–0.79 = moderate, ≥0.80 = large
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