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Table 2 EQ-5D index, VAS scores and ppFEV1 by time since Pulmonary Exacerbation Start

From: Impact of pulmonary exacerbations and lung function on generic health-related quality of life in patients with cystic fibrosis

   EQ-5D Index EQ-5D VAS ppFEV1
n LS Mean (SE) p-value LS Mean (SE) p-value LS Mean (SE) p-value
PE Requiring Hospitalization
 >8 weeks prior 162 0.904 (0.020) <0.001 72.8 (2.1) 0.015 60.9 (2.1) 0.043
 >4–8 weeks prior 27 0.884 (0.030) 0.001 73.3 (3.1) 0.038 60.1 (2.5) 0.226
 >1–4 weeks prior 20 0.905 (0.034) <0.001 73.8 (3.5) 0.046 64.7 (2.6) 0.002
 Within 1 week of start: reference group 23 0.760 (0.033) - 65.3 (3.4) - 57.6 (2.5) -
 >1–4 weeks post 15 0.841 (0.039) 0.084 74.5 (4.0) 0.053 65.5 (2.8) 0.002
 >4–8 weeks post 29 0.847 (0.030) 0.022 72.7 (3.1) 0.052 63.4 (2.4) 0.004
 >8 weeks post 121 0.856 (0.021) 0.002 72.0 (2.2) 0.034 62.7 (2.2) 0.003
PE Not Requiring Hospitalization    
 >8 weeks prior 305a 0.883 (0.016) 0.787 72.1 (1.5) 0.021 59.3 (1.7) 0.029
 >4–8 weeks prior 54 0.912 (0.024) 0.252 73.3 (1.9) 0.014 58.3 (1.8) 0.336
 >1–4 weeks prior 36 0.876 (0.029) 0.988 72.5 (2.2) 0.071 60.6 (1.9) 0.015
 Within 1 week of start: reference group 38 0.876 (0.027) - 68.0 (2.1) - 57.1 (1.9) -
 >1–4 weeks post 33 0.916 (0.029) 0.276 70.6 (2.2) 0.295 57.6 (1.9) 0.753
 >4–8 weeks post 47 0.849 (0.025) 0.396 71.9 (2.0) 0.082 57.5 (1.8) 0.748
 >8 weeks post 210 0.857 (0.017) 0.470 70.2 (1.5) 0.233 58.7 (1.7) 0.115
  1. Abbreviations: ppFEV 1 percent predicted forced expiratory volume in 1 s, VAS visual analog scale score, LS least-squares
  2. a N = 304 observations for ppFEV1