Impact of pulmonary exacerbations and lung function on generic health-related quality of life in patients with cystic fibrosis

Table 2 EQ-5D index, VAS scores and ppFEV₁ by time since Pulmonary Exacerbation Start

		EQ-5D Index		EQ-5D VAS		ppFEV₁
	n	LS Mean (SE)	p-value	LS Mean (SE)	p-value	LS Mean (SE)	p-value
PE Requiring Hospitalization
>8 weeks prior	162	0.904 (0.020)	<0.001	72.8 (2.1)	0.015	60.9 (2.1)	0.043
>4–8 weeks prior	27	0.884 (0.030)	0.001	73.3 (3.1)	0.038	60.1 (2.5)	0.226
>1–4 weeks prior	20	0.905 (0.034)	<0.001	73.8 (3.5)	0.046	64.7 (2.6)	0.002
Within 1 week of start: reference group	23	0.760 (0.033)	-	65.3 (3.4)	-	57.6 (2.5)	-
>1–4 weeks post	15	0.841 (0.039)	0.084	74.5 (4.0)	0.053	65.5 (2.8)	0.002
>4–8 weeks post	29	0.847 (0.030)	0.022	72.7 (3.1)	0.052	63.4 (2.4)	0.004
>8 weeks post	121	0.856 (0.021)	0.002	72.0 (2.2)	0.034	62.7 (2.2)	0.003
PE Not Requiring Hospitalization
>8 weeks prior	305^a	0.883 (0.016)	0.787	72.1 (1.5)	0.021	59.3 (1.7)	0.029
>4–8 weeks prior	54	0.912 (0.024)	0.252	73.3 (1.9)	0.014	58.3 (1.8)	0.336
>1–4 weeks prior	36	0.876 (0.029)	0.988	72.5 (2.2)	0.071	60.6 (1.9)	0.015
Within 1 week of start: reference group	38	0.876 (0.027)	-	68.0 (2.1)	-	57.1 (1.9)	-
>1–4 weeks post	33	0.916 (0.029)	0.276	70.6 (2.2)	0.295	57.6 (1.9)	0.753
>4–8 weeks post	47	0.849 (0.025)	0.396	71.9 (2.0)	0.082	57.5 (1.8)	0.748
>8 weeks post	210	0.857 (0.017)	0.470	70.2 (1.5)	0.233	58.7 (1.7)	0.115

Abbreviations: ppFEV ₁ percent predicted forced expiratory volume in 1 s, VAS visual analog scale score, LS least-squares
^a N = 304 observations for ppFEV₁