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Table 5 Relationship between percent reduction from baseline in BPI Sleep Interference by Pain and improvement on the PGIC

From: Relationship between pain relief, reduction in pain-associated sleep interference, and overall impression of improvement in patients with postherpetic neuralgia treated with extended-release gabapentin

 

≥30 % reduction in BPI Sleep Interference

<30 % reduction in BPI Sleep Interference

Difference

p-value

(n = 301)

(n = 171)

% (95 % CI)

“Much” or “Very Much” improved on PGIC, n (%)

174 (57.8)

46 (26.9)

30.91 (22.23, 39.58)

<0.0001

Not improved on PGICa, n (%)

127 (42.2)

125 (73.1)

−30.91 (−39.58, −22.23)

<0.0001

Difference, % (95 % CI)

15.61 (7.72, 23.50)

−46.29 (−55.60, −36.80)

n/a

n/a

p-value

0.0001

<0.0001

n/a

n/a

  1. aIncludes patients from other PGIC categories: Minimally Improved, No Change, Minimally Worse, Much Worse, Very Much Worse; n/a, not applicable