Skip to main content

Advertisement

Table 4 Prognostic Effect of BPI-SF and RSCL on Survival

From: Patient-reported pain and other quality of life domains as prognostic factors for survival in a phase III clinical trial of patients with advanced breast cancer

HRQOL subscale variables a n b HR 95 % CI p-value HR 95 % CI p-value
  Univariate Multivariatec
BPI-SF – Pain Interference 282 1.07 1.02–1.12 0.0061 1.02 0.97–1.08 0.3931
BPI-SF – Worst Pain 279 1.07 1.03–1.12 0.0013 1.05 1.00–1.10 0.0342
RSCL – Activity Level 330 0.86 0.82–0.91 <0.0001 0.89 0.83–0.95 0.0004
RSCL – Physical Distress 333 0.88 0.81–0.97 0.0104 0.92 0.83–1.02 0.1053
RSCL – Psychological Distress 332 0.96 0.91–1.01 0.1025 0.98 0.92–1.03 0.3800
RSCL – HRQOL 324 0.91 0.87–0.96 0.0002 0.95 0.90–1.01 0.0810
  1. BPI-SF Brief Pain Inventory-Short Form; CI confidence interval; HR hazard ratio; HRQOL health-related quality of life; KPS Karnofsky Performance Status; n number of patients with nonmissing values on a variable among randomized patients; RSCL Rotterdam Symptom Checklist
  2. aHRs for every 1-point increase in the BPI-SF and every 10-point increase in the RSCL subscales
  3. bIncludes 1 patient with missing KPS score and not included in Tables 2 and 3. This patient’s scores were as follows: BPI Pain Interference, 0; BPI Worst Pain, 0; RSCL Activity, 100; RSCL Physical, missing; RSCL Psychological, missing; RSCL HRQOL, 83.33
  4. cMultivariate Cox proportional hazards models were used to determine each HR in the presence of 11 demographic/clinical variables: age, race, KPS, estrogen receptor status, progesterone receptor status, presence of visceral disease, prior radiotherapy, prior hormonal treatment, menopausal status, basis for pathological diagnosis, and pathological diagnosis