Patient-reported pain and other quality of life domains as prognostic factors for survival in a phase III clinical trial of patients with advanced breast cancer

Table 3 Mean RSCL^a Subscale Scores by KPS

KPS	RSCL – Activity		RSCL – Physical		RSCL – Psych		RSCL – HRQOL
	n	Mean (SD)	n	Mean (SD)	n	Mean (SD)	n	Mean (SD)
Overall^b	329	83.3 (22.65)	333	83.5 (12.37)	332	64.4 (23.76)	323	66.0 (24.14)
≤70	25	51.2 (27.11)	26	74.4 (14.21)	26	56.5 (26.78)	26	38.5 (28.19)
80	58	71.7 (26.25)	59	78.5 (12.27)	58	60.3 (23.31)	58	58.6 (22.13)
90	110	85.2 (18.62)	111	84.9 (11.75)	111	65.1 (24.19)	109	67.1 (22.39)
100	136	92.7 (14.32)	137	86.2 (11.17)	137	67.1 (22.67)	130	74.0 (20.54)
		p = 0.0001^c		p < 0.0001^c		p = 0.1630^c		p < 0.0001^c

Activity: Activity level; Physical: Physical distress; Psych: Psychological distress
HRQOL health-related quality of life; KPS Karnofsky Performance Status; RSCL Rotterdam Symptom Checklist; SD standard deviation
^a RSCL scores transformed to a range from 0 to 100, with 100 as best score
^b Overall patient numbers < 336 because not all answered every RSCL item
^c p-values derived from one-way analysis of variance