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Table 3 Drop in SF-36 and CLDQ-HCV HRQoL scores from antiviral baseline to end of ATV treatment, and at the 24-week post-treatment follow-up by treatment group

From: Health-related quality of life in thrombocytopenic patients with chronic hepatitis C with or without cirrhosis in the ENABLE-1 and ENABLE-2 studies

  Drop in ATV BL to End of Treatment Mean (95 % CI) Drop in ATV BL to 24-week FU Mean (95 % CI)
  PBO EPAG Cohen’s d PBO EPAG Cohen’s d
SF-36v2 acute       
Physical functioning −5.2 (−6.1, −4.4) 4.8 (−5.4, −4.2) 0.05 −2.2 (−3.1, −1.4) −1.6 (−2.2, −1.0) 0.08
Role-physical −4.7 (−5.7, −3.8) −5.5 (−6.2, −4.8) −0.08 2.4 (−3.3, −1.4) −2.2 (−2.9, −1.6) 0.02
Bodily pain −4.6 (−5.6, −3.7) −4.8 (−5.5, −4.1) −0.02 2.3 (−3.4, −1.3) −1.7 (−2.4, −1.0) 0.06
General health −3.8 (−4.5, −3.0) −2.9 (−3.4, −2.3) 0.11 2.3 (−3.1, −1.4) −1.8 (−2.4, −1.2) 0.06
Vitality −6.0 (−7.0, −5.1) −6.1 (−6.7, −5.4) −0.00 −2.1 (−3.0, −1.2) −1.4 (−2.1, −0.8) 0.07
Social functioning −5.3 (−6.3, −4.3) −6.5 (−7.3, −5.8) −0.12 2.5 (−3.5, −1.6), −2.2 (−2.9, −1.5) −0.12
Role-emotional −5.3 (−6.5, −4.0) −6.8 (−7.7, −5.8) −0.11 −3.1 (−4.2, −2.0) −2.8 (−3.7, −1.9) 0.03
Mental health −5.8 (−6.7, −4.9) −5.3 (−6.0, −4.6) 0.05 −2.1 (−3.0, −1.1) −1.7 (−2.4, −1.1) 0.07
PCSa −5.8 (−6.6, −5.0) −6.2 (−6.8, −5.6) −0.05 −2.8 (−3.6, −1.9) −2.3 (−2.8, −1.7) 0.03
MCSa −6.3 (−7.2, −5.4) −6.4 (−7.1, −5.8) −0.02 −2.6 (−3.5, −1.7) −2.1 (−2.7, −1.5) 0.06
CLDQ-HCV       
Overall −0.6 (−0.7, −0.5) −0.6 (−0.6, −0.5) 0.02 −0.3 (−0.4, −0.2) −0.2 (−0.3, −0.2) 0.06
Activity −5.6 (−6.3, −4.8) −5.6 (−6.2, −5.1) −0.01 −1.9 (−2.7, −1.2) −1.8 (−2.3, −1.3) 0.02
Emotion −4.8 (−5.7, −3.8) −4.5 (−5.1, −3.9) 0.03 −1.9 (−2.8, −1.0) −1.8 (−2.4, −1.1) 0.02
Systemic symptoms −4.0 (−4.6, −3.3) −4.0 (−4.4, −3.5) −0.00 −2.3 (−3.0, −1.6) −1.7 (−2.2, −1.3) 0.09
Worry −2.5 (−3.4, −1.6) −1.8 (−2.4, −1.2) 0.07 −1.7 (−2.7, −0.7) −0.9 (−1.6, −0.2) 0.08
  1. CI confidence interval, CLDQ-HCV chronic liver disease questionnaire–hepatitis C virus version, MCS mental component summary, PCS physical component summary, SF-36v2 short-form 36 health survey version 2
  2. aScored as a correlated physical and mental health factor model [24]