Patient Uncertainty Questionnaire-Rheumatology (PUQ-R): development and validation of a new patient-reported outcome instrument for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a mixed methods study

Cleanthous, Sophie; Isenberg, David Alan; Newman, Stanton Peter; Cano, Stefan John

doi:10.1186/s12955-016-0432-8

Table 3 PUQ-R measurement scales item-level data

From: Patient Uncertainty Questionnaire-Rheumatology (PUQ-R): development and validation of a new patient-reported outcome instrument for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a mixed methods study

Item String		Loc.	SE	Fit Res.	Chi Sq.	Prob.	res. r	DIF ANOVA (df = 1)
Item String		Loc.	SE	Fit Res.	Chi Sq.	Prob.	res. r	MS	F	Prob.
PUQ-R Symptoms & Flares Scale (PSI = 0.91)
1	straight away	−1.82	0.11	−2.00	14.09	0.00	0.33	5.93	8.68	0.00
2	specific symptoms	−1.64	0.10	−0.98	3.39	0.34	<0.30	1.31	1.57	0.21
3	everyday symptoms	−1.22	0.10	−0.40	5.48	0.14	0.33	2.51	2.90	0.09
4	serious symptoms	−1.12	0.09	0.40	0.87	0.83	<0.30	0.90	0.93	0.34
5	getting older	−1.04	0.09	0.80	2.75	0.43	<0.30	1.91	1.91	0.17
6	side-effects	−0.87	0.09	2.35	4.48	0.21	<0.30	0.36	0.31	0.58
7	all different	−0.80	0.09	−0.89	10.36	0.02	<0.30	0.08	0.10	0.76
8SLE	symptom triggers	−0.39	0.10	2.09	11.03	0.01	0.37	0.00	0.00	1.00
9	flare type	0.36	0.08	−0.24	2.99	0.39	<0.30	2.09	2.33	0.13
10	symptom timing	0.46	0.09	0.84	1.79	0.62	0.37	2.27	2.24	0.14
8RA	symptom triggers	0.80	0.14	2.05	7.49	0.06	<0.30	0.00	0.00	1.00
11	future effect	1.21	0.09	1.44	3.75	0.29	0.42	0.29	0.26	0.61
12	flare timing	1.39	0.10	0.11	7.08	0.07	0.32	8.93	10.13	0.00
13	flare severity	2.11	0.11	−0.38	1.67	0.64	0.51	2.40	2.77	0.10
14	flare frequency	2.57	0.12	−1.12	5.15	0.16	0.51	0.67	0.88	0.35
PUQ-R Medication Scale (PSI = 0.91)
15RA	need medication	−1.54	0.17	−0.96	1.81	0.61	0.32	0.00	0.00	1.00
16	help symptoms	−0.91	0.10	−0.75	1.38	0.71	0.44	27.30	39.46	0.00
17	controls condition	−0.56	0.09	−1.23	5.21	0.16	0.49	1.02	1.34	0.25
15SLE	need medication	−0.52	0.11	2.56	31.68	0.00	0.49	0.00	0.00	1.00
18	stronger dose	−0.24	0.09	−0.68	3.32	0.34	0.48	2.01	2.44	0.12
19	will help symptoms	−0.20	0.10	0.63	1.80	0.61	0.51	0.22	0.23	0.63
20	need additional	−0.08	0.09	−1.61	5.27	0.15	0.52	0.25	0.33	0.57
21	need alternative	0.05	0.09	0.16	0.21	0.98	0.52	0.66	0.71	0.40
22	will control	0.07	0.10	0.43	2.44	0.49	0.51	0.04	0.04	0.84
23	will need stronger	1.22	0.09	−0.30	2.18	0.54	0.75	4.38	5.13	0.02
24	will need additional	1.32	0.10	0.66	4.21	0.24	0.75	2.98	3.24	0.07
25	will not alternative	1.37	0.09	1.05	2.26	0.52	0.62	0.29	0.28	0.60
Item		Loc.	SE	Fit Res.	Chi Sq.	Prob.	res. r	DIF ANOVA (df = 1)
Item		Loc.	SE	Fit Res.	Chi Sq.	Prob.	res. r	MS	F	Prob.
PUQ-R Trust in Doctor Scale (PSI = 0.73)
26	best dose	−1.16	0.11	−2.75	16.24	0.00	0.71	0.76	1.29	0.26
27	which medication	−1.10	0.11	−2.66	22.06	0.00	0.71	1.43	2.49	0.12
28	help physical	−0.88	0.10	−1.15	10.30	0.02	<0.30	3.69	5.09	0.02
29	what’s wrong	−0.67	0.10	0.37	4.05	0.26	<0.30	1.95	2.16	0.14
30	physically active	−0.19	0.10	−1.59	8.02	0.05	<0.30	0.13	0.18	0.67
31	help non-physical	0.67	0.09	1.28	1.41	0.70	<0.30	0.21	0.21	0.65
32	future progress	1.61	0.09	1.63	1.52	0.68	<0.30	4.56	4.45	0.04
33	cause	1.72	0.08	4.23^a	36.72	0.00^b	<0.30	0.24	0.17	0.68
PUQ-R Self-management Scale (PSI = 0.86)
34	questions	−0.52	0.10	0.93	10.46	0.02	<0.30	0.55	0.59	0.44
35	symptom report	−0.49	0.11	−0.56	3.69	0.30	<0.30	4.20	5.60	0.02
36	test results	0.11	0.09	0.91	3.65	0.30	<0.30	6.49	7.34	0.01
37	activities to avoid	0.15	0.09	0.10	1.84	0.61	<0.30	0.06	0.07	0.79
38	how to manage	0.32	0.10	−1.11	9.91	0.02	<0.30	3.19	4.61	0.03
39	help control	0.43	0.09	0.93	7.34	0.06	<0.30	2.50	2.81	0.10
PUQ-R Impact Scale (PSI = 0.87)
40	education	−1.24	0.16	0.56	1.20	0.75	<0.30	0.48	0.47	0.49
41	relationship	−0.91	0.10	2.11	15.09	0.00^b	0.32	9.20	8.89	0.00
42	children	−0.53	0.13	1.66	5.36	0.15	0.32	4.41	4.21	0.04
43	plan life	0.01	0.10	−1.92	13.60	0.00	<0.30	1.57	2.39	0.12
44	finances	0.02	0.09	1.10	1.73	0.63	<0.30	0.00	0.00	0.97
45	functionality	0.12	0.10	−3.60^a	14.73	0.00^b	<0.30	8.29	16.21	0.00^c
46	exercise	0.46	0.10	0.48	1.46	0.69	<0.30	0.55	0.61	0.44
47	mobility	0.54	0.09	−1.36	7.06	0.07	<0.30	5.21	7.45	0.01
48	job prospects	0.54	0.11	−0.58	5.71	0.13	<0.30	0.71	0.94	0.33
49	pregnancy	0.99	0.16	3.31^a	27.10	0.00^b	<0.30	0.63	0.32	0.58

Loc item Location; SE standard error; res. r residual correlation; DIF differential item functioning
^afit residuals outside the recommended range is −2.5 to +2.5
^bChi-square probability significant after Bonferroni adjustment at p < 0.01
^cDIF by patient group (SLE Vs RA) significant after Bonferroni adjustment at <0.01

Back to article page

ISSN: 1477-7525

Contact us

Submission enquiries: journalsubmissions@springernature.com

Health and Quality of Life Outcomes

Contact us