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Table 4 ROC statistics for a 1-point change in rating of concept and rating of change at weeks 2 (no recent fracture patients) and 12 (recent fracture patients): Area Under the Curve (AUC), Best Cut Point (BCP) with values of sensitivity (Se) and specificity (Sp) of OPAQ-PF change scores

From: Interpreting change from patient reported outcome (PRO) endpoints: patient global ratings of concept versus patient global ratings of change, a case study among osteoporosis patients

  No recent fracture patients Recent fracture patients
Week 2 Week 12
N (%) AUC (95 % CI) BCP (Se, Sp) N (%) AUC (95 % CI) BCP (Se, Sp)
Ratings of change
 Mobility 13
(12)
0.41 (0.26-0.57)
p = 0.31
−6.67
(0.77, 0.27)
21
(62)
0.71 (0.54, 0.89)
p = 0.038
10.67
(0.71, 0.69)
 Physical positions 12
(11)
0.37 (0.22-0.52)
p = 0.14
−6.67
(0.75, 0.27)
19
(56)
0.78 (0.62-0.94)
p < 0.001
10.67
(0.79, 0.73)
 Transfers 11
(11)
0.37 (0.21-0.53)
p = 0.16
−6.67
(0.73, 0.27)
19
(56)
0.74 (0.56-0.91)
p = 0.022
10.67
(0.79,0.71)
Mean AUC/BCP
Mean (Se, Sp)
0.38 −6.67
(0.75, 0.27)
  0.74 10.67
(0.76, 0.71)
Overall mean AUC
Mean (Se, Sp)
0.56 (range = 0.37 to 0.78)
(0.76, 0.49)
Ratings of concept
 Mobility 16(15) 0.60 (0.43-0.78)
p = 0.19
2.0
(0.50, 0.79)
18
(53)
0.74 (0.57-0.91)
p = 0.016
10.67
(0.78, 0.69)
 Physical positions 21(20) 0.63 (0.49-0.77)
p = 0.075
1.33
(0.48, 0.23)
16
(47)
0.87 (0.75-1.00)
p < 0.001
12.0
(0.88, 0.78)
 Transfers 22
(21)
0.68 (0.55-0.82)
p = 0.008
0.67
(0.59, 0.77)
13
(41)
0.82 (0.66-0.98)
p = 0.002
12.67
(0.85, 0.68)
Mean AUC/BCP
>Mean (Se, Sp)
0.64 1.33
(0.52, 0.60)
  0.81 11.78
(0.84, 0.72)
Overall mean AUC
Mean (Se, Sp)
0.73 (range = 0.60 to 0.87)
(0.68, 0.66)