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Table 4 ROC statistics for a 1-point change in rating of concept and rating of change at weeks 2 (no recent fracture patients) and 12 (recent fracture patients): Area Under the Curve (AUC), Best Cut Point (BCP) with values of sensitivity (Se) and specificity (Sp) of OPAQ-PF change scores

From: Interpreting change from patient reported outcome (PRO) endpoints: patient global ratings of concept versus patient global ratings of change, a case study among osteoporosis patients

 

No recent fracture patients

Recent fracture patients

Week 2

Week 12

N (%)

AUC (95 % CI)

BCP (Se, Sp)

N (%)

AUC (95 % CI)

BCP (Se, Sp)

Ratings of change

 Mobility

13

(12)

0.41 (0.26-0.57)

p = 0.31

−6.67

(0.77, 0.27)

21

(62)

0.71 (0.54, 0.89)

p = 0.038

10.67

(0.71, 0.69)

 Physical positions

12

(11)

0.37 (0.22-0.52)

p = 0.14

−6.67

(0.75, 0.27)

19

(56)

0.78 (0.62-0.94)

p < 0.001

10.67

(0.79, 0.73)

 Transfers

11

(11)

0.37 (0.21-0.53)

p = 0.16

−6.67

(0.73, 0.27)

19

(56)

0.74 (0.56-0.91)

p = 0.022

10.67

(0.79,0.71)

Mean AUC/BCP

Mean (Se, Sp)

0.38

−6.67

(0.75, 0.27)

 

0.74

10.67

(0.76, 0.71)

Overall mean AUC

Mean (Se, Sp)

0.56 (range = 0.37 to 0.78)

(0.76, 0.49)

Ratings of concept

 Mobility

16(15)

0.60 (0.43-0.78)

p = 0.19

2.0

(0.50, 0.79)

18

(53)

0.74 (0.57-0.91)

p = 0.016

10.67

(0.78, 0.69)

 Physical positions

21(20)

0.63 (0.49-0.77)

p = 0.075

1.33

(0.48, 0.23)

16

(47)

0.87 (0.75-1.00)

p < 0.001

12.0

(0.88, 0.78)

 Transfers

22

(21)

0.68 (0.55-0.82)

p = 0.008

0.67

(0.59, 0.77)

13

(41)

0.82 (0.66-0.98)

p = 0.002

12.67

(0.85, 0.68)

Mean AUC/BCP

>Mean (Se, Sp)

0.64

1.33

(0.52, 0.60)

 

0.81

11.78

(0.84, 0.72)

Overall mean AUC

Mean (Se, Sp)

0.73 (range = 0.60 to 0.87)

(0.68, 0.66)