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Table 2 Mean OPAQ-PF total scores at baseline, change scores, and effect sizes at weeks 2 (no recent fracture patients) and 12 (recent fracture patients) by changes in patient global ratings of concept at weeks 2 and 12

From: Interpreting change from patient reported outcome (PRO) endpoints: patient global ratings of concept versus patient global ratings of change, a case study among osteoporosis patients

  No recent fracture patients (N = 105) Recent fracture patients (N = 34)
Change in rating of concept   Baseline 2 weeks Effect sizea for OPAQ-PF change   Baseline 12 weeks Effect sizea for OPAQ-PF change
N OPAQ-PF total score
mean (SD)
OPAQ-PF mean change (SD) N OPAQ-PF total score
mean (SD)
OPAQ-PF mean change (SD)
Mobility
 3 or 4 0 - - - 2 63.3 (51.9) 22.7 (71.7) 0.44
 2 4 80.0 (26.8) 2.33 (24.2) 0.09 4 42.3 (6.00) 37.7 (16.1) 6.28
 1 12 84.6 (14.5) 2.33 (12.0) 0.16 12 55.9 (20.6) 19.0 (18.0) 0.92
 0 72 81.1 (22.6) −2.54 (8.89) −0.11 15 64.4 (28.6) 3.91 (21.7) 0.14
 −1 14 83.9 (22.3) −3.33 (8.57) −0.15 1 69.3 −9.33 -
 −2 3 69.6 (30.3) −6.49 (13.1) −0.21 0 - - -
 −3 or −4 0 - - - 0 - - -
  K-W test p-value 0.475     0.069  
  Linear trend p-value
(departures from linear trend)
0.079 (0.848)     0.015 (0.606)  
  rs
(p-value)
0.152 (0.122)     0.464 (0.006)  
Physical Positions
 3 or 4 0 - - - 3 38.2 (10.1) 50.2 (27.4) 4.97
 2 5 61.3 (35.1) 4.80 (17.6) 0.14 6 44.4 (10.3) 35.8 (13.4) 3.48
 1 16 83.5 (17.2) 0.00 (5.74) 0.0 7 61.7 (17.4) 14.3 (18.5) 0.82
 0 65 82.4 (21.8) −1.83 (10.2) 0.08 11 59.2 (34.4) 3.39 (22.1) 0.10
 −1 17 81.0 (21.2) −6.40 (9.80) −0.31 7 77.0 (15.7) −4.19 (13.9) −0.27
 −2 2 94.0 (6.60) −4.00 (7.54) −0.61 0 - - -
 −3 or −4 0 - - - 0 - - -
  K-W test p-value 0.150     <0.005  
  Linear trend p-value
(departures from linear trend)
0.021 (0.840)     <0.001 (0.763)  
  rs
(p-value)
0.247 (0.011)     0.749 (<.001)  
Transfersb
 3 or 4 1 73.3 (−) 6.67 (−) - 2 44.0 (1.89) 38.7 (26.4) 20.5
 2 4 64.7 (23.4) 1.33 (16.7) 0.12 7 45.2 (15.3) 37.0 (22.5) 2.42
 1 17 79.1 (15.5) 0.78 (6.00) 0.05 4 65.7 (31.2) 13.3 (28.9) 0.43
 0 62 84.8 (22.4) −1.96 (10.3) −0.09 15 64.4 (29.9) 2.58 (20.5) 0.09
 −1 17 78.2 (24.4) −4.91 (9.99) −0.20 3 64.0 (13.1) 14.2 (16.9) 0.83
 −2 2 76.7 (2.83) −17.3 (5.66) −6.11 1 40.0 (−) 10.7 (−) -
 −3 or −4 0 - - - 0 - - -
  K-W test 0.015     0.063  
  Linear trend p-value
(departures from linear trend)
0.010 (0.742)     0.005 (0.332)  
  rs
(p-value)
0.318 (0.001)     0.503 (0.003)  
  1. Data are shown for patients with data at each two assessments
  2. aCohen’s d effect size = mean change / baseline SD
  3. b N = 103 (no recent fracture) N = 32 (recent fracture)