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Table 2 Mean OPAQ-PF total scores at baseline, change scores, and effect sizes at weeks 2 (no recent fracture patients) and 12 (recent fracture patients) by changes in patient global ratings of concept at weeks 2 and 12

From: Interpreting change from patient reported outcome (PRO) endpoints: patient global ratings of concept versus patient global ratings of change, a case study among osteoporosis patients

 

No recent fracture patients (N = 105)

Recent fracture patients (N = 34)

Change in rating of concept

 

Baseline

2 weeks

Effect sizea for OPAQ-PF change

 

Baseline

12 weeks

Effect sizea for OPAQ-PF change

N

OPAQ-PF total score

mean (SD)

OPAQ-PF mean change (SD)

N

OPAQ-PF total score

mean (SD)

OPAQ-PF mean change (SD)

Mobility

 3 or 4

0

-

-

-

2

63.3 (51.9)

22.7 (71.7)

0.44

 2

4

80.0 (26.8)

2.33 (24.2)

0.09

4

42.3 (6.00)

37.7 (16.1)

6.28

 1

12

84.6 (14.5)

2.33 (12.0)

0.16

12

55.9 (20.6)

19.0 (18.0)

0.92

 0

72

81.1 (22.6)

−2.54 (8.89)

−0.11

15

64.4 (28.6)

3.91 (21.7)

0.14

 −1

14

83.9 (22.3)

−3.33 (8.57)

−0.15

1

69.3

−9.33

-

 −2

3

69.6 (30.3)

−6.49 (13.1)

−0.21

0

-

-

-

 −3 or −4

0

-

-

-

0

-

-

-

 

K-W test p-value

0.475

   

0.069

 
 

Linear trend p-value

(departures from linear trend)

0.079 (0.848)

   

0.015 (0.606)

 
 

rs

(p-value)

0.152 (0.122)

   

0.464 (0.006)

 

Physical Positions

 3 or 4

0

-

-

-

3

38.2 (10.1)

50.2 (27.4)

4.97

 2

5

61.3 (35.1)

4.80 (17.6)

0.14

6

44.4 (10.3)

35.8 (13.4)

3.48

 1

16

83.5 (17.2)

0.00 (5.74)

0.0

7

61.7 (17.4)

14.3 (18.5)

0.82

 0

65

82.4 (21.8)

−1.83 (10.2)

0.08

11

59.2 (34.4)

3.39 (22.1)

0.10

 −1

17

81.0 (21.2)

−6.40 (9.80)

−0.31

7

77.0 (15.7)

−4.19 (13.9)

−0.27

 −2

2

94.0 (6.60)

−4.00 (7.54)

−0.61

0

-

-

-

 −3 or −4

0

-

-

-

0

-

-

-

 

K-W test p-value

0.150

   

<0.005

 
 

Linear trend p-value

(departures from linear trend)

0.021 (0.840)

   

<0.001 (0.763)

 
 

rs

(p-value)

0.247 (0.011)

   

0.749 (<.001)

 

Transfersb

 3 or 4

1

73.3 (−)

6.67 (−)

-

2

44.0 (1.89)

38.7 (26.4)

20.5

 2

4

64.7 (23.4)

1.33 (16.7)

0.12

7

45.2 (15.3)

37.0 (22.5)

2.42

 1

17

79.1 (15.5)

0.78 (6.00)

0.05

4

65.7 (31.2)

13.3 (28.9)

0.43

 0

62

84.8 (22.4)

−1.96 (10.3)

−0.09

15

64.4 (29.9)

2.58 (20.5)

0.09

 −1

17

78.2 (24.4)

−4.91 (9.99)

−0.20

3

64.0 (13.1)

14.2 (16.9)

0.83

 −2

2

76.7 (2.83)

−17.3 (5.66)

−6.11

1

40.0 (−)

10.7 (−)

-

 −3 or −4

0

-

-

-

0

-

-

-

 

K-W test

0.015

   

0.063

 
 

Linear trend p-value

(departures from linear trend)

0.010 (0.742)

   

0.005 (0.332)

 
 

rs

(p-value)

0.318 (0.001)

   

0.503 (0.003)

 
  1. Data are shown for patients with data at each two assessments
  2. aCohen’s d effect size = mean change / baseline SD
  3. b N = 103 (no recent fracture) N = 32 (recent fracture)