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Table 3 PRO-CTCAE Item scores by tablet, IVRS and paper modes of administration

From: Mode equivalence and acceptability of tablet computer-, interactive voice response system-, and paper-based administration of the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)

PRO-CTCAE Item

Item Score

Difference in Item Scores by Mode

 

Mean (SD)

Mean Difference (95 % CI)

 

Tablet

Tablet – IVRS

Tablet – Paper

IVRS – Paper

Anxiety (F)

1.41 (0.90)

−0.11 (−0.24, 0.03)

−0.02 (−0.15, 0.11)

0.08 (−0.05, 0.21)

Anxiety (S)

0.62 (0.84)

−0.03 (−0.16, 0.09)

0.00 (−0.13, 0.13)

0.03 (−0.09, 0.16)

Anxiety (I)

1.20 (0.84)

−0.14 (−0.27, −0.01)

−0.06 (−0.20, 0.07)

0.08 (−0.05, 0.21)

Constipation (S)

0.80 (0.99)

−0.12 (−0.26, 0.02)

0.01 (−0.13, 0.15)

0.13 (−0.01, 0.27)

Decreased appetite (S)

0.62 (0.92)

−0.14 (−0.28, −0.01)

0.05 (−0.08, 0.18)

0.19 (0.06, 0.32)

Decreased appetite (I)

0.93 (1.03)

−0.03 (−0.16, 0.10)

0.07 (−0.06, 0.20)

0.10 (−0.04, 0.23)

Fatigue, tiredness, or lack of energy (S)

1.40 (1.17)

−0.16 (−0.30, −0.02)

−0.04 (−0.18, 0.10)

0.12 (−0.02, 0.26)

Fatigue, tiredness, or lack of energy (I)

1.53 (1.11)

−0.07 (−0.23, 0.10)

0.11 (−0.05, 0.28)

0.18 (0.02, 0.35)

Insomnia (S)

0.96 (1.19)

−0.05 (−0.17, 0.08)

0.05 (−0.08, 0.18)

0.10 (−0.03, 0.22)

Insomnia (I)

1.32 (1.22)

−0.08 (−0.22, 0.06)

−0.11 (−0.26, 0.03)

−0.03 (−0.17, 0.11)

Loose or watery stools (F)

0.79 (0.99)

−0.01 (−0.13, 0.11)

−0.01 (−0.13, 0.11)

0.00 (−0.11, 0.12)

Mouth or throat sores (S)

0.21 (0.56)

−0.03 (−0.12, 0.07)

0.01 (−0.08, 0.10)

0.04 (−0.06, 0.13)

Mouth or throat sores (I)

0.40 (0.74)

−0.01 (−0.12, 0.10)

−0.08 (−0.19, 0.04)

−0.07 (−0.18, 0.05)

Nausea (F)

0.92 (1.16)

−0.08 (−0.19, 0.03)

−0.05 (−0.15, 0.06)

0.03 (−0.07, 0.14)

Nausea (S)

0.75 (0.95)

−0.09 (−0.19, 0.01)

−0.06 (−0.17, 0.04)

0.02 (−0.08, 0.12)

Numbness/tingling in hands/feet (S)

0.70 (1.06)

−0.13 (−0.23, −0.04)

0.00 (−0.09, 0.10)

0.14 (0.04, 0.23)

Numbness/tingling in hands/feet (I)

0.89 (1.03)

0.08 (−0.04, 0.19)

0.04 (−0.08, 0.16)

−0.03 (−0.15, 0.08)

Pain (F)

1.34 (1.29)

−0.05 (−0.15, 0.06)

0.02 (−0.09, 0.13)

0.07 (−0.04, 0.17)

Pain (S)

1.06 (1.19)

0.01 (−0.10, 0.12)

−0.02 (−0.14, 0.09)

−0.03 (−0.14, 0.08)

Pain (I)

1.25 (1.20)

−0.04 (−0.19, 0.11)

−0.03 (−0.18, 0.13)

0.01 (−0.15, 0.16)

Rash (P)

0.11 (0.32)

−0.03 (−0.08, 0.02)

−0.04 (−0.09, 0.01)

−0.01 (−0.06, 0.04)

Sad or unhappy feelings (F)

1.44 (0.98)

0.12 (0.00, 0.24)

0.14 (0.02, 0.26)

0.02 (−0.10, 0.14)

Sad or unhappy feelings (S)

0.70 (0.91)

0.03 (−0.08, 0.14)

−0.01 (−0.12, 0.10)

−0.04 (−0.15, 0.07)

Sad or unhappy feelings (I)

1.11 (0.83)

0.05 (−0.08, 0.18)

0.01 (−0.12, 0.15)

−0.03 (−0.17, 0.10)

Shortness of breath (S)

0.51 (0.83)

−0.04 (−0.11, 0.04)

−0.05 (−0.12, 0.03)

−0.01 (−0.09, 0.07)

Shortness of breath (I)

0.57 (0.77)

−0.07 (−0.19, 0.05)

−0.10 (−0.22, 0.02)

−0.03 (−0.15, 0.09)

Vomiting (F)

0.29 (0.65)

−0.02 (−0.08, 0.05)

−0.02 (−0.09, 0.04)

0.00 (−0.07, 0.06)

Vomiting (S)

0.27 (0.64)

0.00 (−0.07, 0.07)

−0.06 (−0.13, 0.02)

−0.06 (−0.13, 0.02)

  1. Abbreviations: PRO-CTCAE Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, F Frequency, S Severity, I Interference, P Presence/Absence, SD Standard Deviation, CI Confidence Interval, IVRS Interactive Voice Response System