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Table 3 PRO-CTCAE Item scores by tablet, IVRS and paper modes of administration

From: Mode equivalence and acceptability of tablet computer-, interactive voice response system-, and paper-based administration of the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)

PRO-CTCAE Item Item Score Difference in Item Scores by Mode
  Mean (SD) Mean Difference (95 % CI)
  Tablet Tablet – IVRS Tablet – Paper IVRS – Paper
Anxiety (F) 1.41 (0.90) −0.11 (−0.24, 0.03) −0.02 (−0.15, 0.11) 0.08 (−0.05, 0.21)
Anxiety (S) 0.62 (0.84) −0.03 (−0.16, 0.09) 0.00 (−0.13, 0.13) 0.03 (−0.09, 0.16)
Anxiety (I) 1.20 (0.84) −0.14 (−0.27, −0.01) −0.06 (−0.20, 0.07) 0.08 (−0.05, 0.21)
Constipation (S) 0.80 (0.99) −0.12 (−0.26, 0.02) 0.01 (−0.13, 0.15) 0.13 (−0.01, 0.27)
Decreased appetite (S) 0.62 (0.92) −0.14 (−0.28, −0.01) 0.05 (−0.08, 0.18) 0.19 (0.06, 0.32)
Decreased appetite (I) 0.93 (1.03) −0.03 (−0.16, 0.10) 0.07 (−0.06, 0.20) 0.10 (−0.04, 0.23)
Fatigue, tiredness, or lack of energy (S) 1.40 (1.17) −0.16 (−0.30, −0.02) −0.04 (−0.18, 0.10) 0.12 (−0.02, 0.26)
Fatigue, tiredness, or lack of energy (I) 1.53 (1.11) −0.07 (−0.23, 0.10) 0.11 (−0.05, 0.28) 0.18 (0.02, 0.35)
Insomnia (S) 0.96 (1.19) −0.05 (−0.17, 0.08) 0.05 (−0.08, 0.18) 0.10 (−0.03, 0.22)
Insomnia (I) 1.32 (1.22) −0.08 (−0.22, 0.06) −0.11 (−0.26, 0.03) −0.03 (−0.17, 0.11)
Loose or watery stools (F) 0.79 (0.99) −0.01 (−0.13, 0.11) −0.01 (−0.13, 0.11) 0.00 (−0.11, 0.12)
Mouth or throat sores (S) 0.21 (0.56) −0.03 (−0.12, 0.07) 0.01 (−0.08, 0.10) 0.04 (−0.06, 0.13)
Mouth or throat sores (I) 0.40 (0.74) −0.01 (−0.12, 0.10) −0.08 (−0.19, 0.04) −0.07 (−0.18, 0.05)
Nausea (F) 0.92 (1.16) −0.08 (−0.19, 0.03) −0.05 (−0.15, 0.06) 0.03 (−0.07, 0.14)
Nausea (S) 0.75 (0.95) −0.09 (−0.19, 0.01) −0.06 (−0.17, 0.04) 0.02 (−0.08, 0.12)
Numbness/tingling in hands/feet (S) 0.70 (1.06) −0.13 (−0.23, −0.04) 0.00 (−0.09, 0.10) 0.14 (0.04, 0.23)
Numbness/tingling in hands/feet (I) 0.89 (1.03) 0.08 (−0.04, 0.19) 0.04 (−0.08, 0.16) −0.03 (−0.15, 0.08)
Pain (F) 1.34 (1.29) −0.05 (−0.15, 0.06) 0.02 (−0.09, 0.13) 0.07 (−0.04, 0.17)
Pain (S) 1.06 (1.19) 0.01 (−0.10, 0.12) −0.02 (−0.14, 0.09) −0.03 (−0.14, 0.08)
Pain (I) 1.25 (1.20) −0.04 (−0.19, 0.11) −0.03 (−0.18, 0.13) 0.01 (−0.15, 0.16)
Rash (P) 0.11 (0.32) −0.03 (−0.08, 0.02) −0.04 (−0.09, 0.01) −0.01 (−0.06, 0.04)
Sad or unhappy feelings (F) 1.44 (0.98) 0.12 (0.00, 0.24) 0.14 (0.02, 0.26) 0.02 (−0.10, 0.14)
Sad or unhappy feelings (S) 0.70 (0.91) 0.03 (−0.08, 0.14) −0.01 (−0.12, 0.10) −0.04 (−0.15, 0.07)
Sad or unhappy feelings (I) 1.11 (0.83) 0.05 (−0.08, 0.18) 0.01 (−0.12, 0.15) −0.03 (−0.17, 0.10)
Shortness of breath (S) 0.51 (0.83) −0.04 (−0.11, 0.04) −0.05 (−0.12, 0.03) −0.01 (−0.09, 0.07)
Shortness of breath (I) 0.57 (0.77) −0.07 (−0.19, 0.05) −0.10 (−0.22, 0.02) −0.03 (−0.15, 0.09)
Vomiting (F) 0.29 (0.65) −0.02 (−0.08, 0.05) −0.02 (−0.09, 0.04) 0.00 (−0.07, 0.06)
Vomiting (S) 0.27 (0.64) 0.00 (−0.07, 0.07) −0.06 (−0.13, 0.02) −0.06 (−0.13, 0.02)
  1. Abbreviations: PRO-CTCAE Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, F Frequency, S Severity, I Interference, P Presence/Absence, SD Standard Deviation, CI Confidence Interval, IVRS Interactive Voice Response System