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Table 1 Different definitions and their cut-offs used to define the metabolic syndrome

From: Which insulin resistance-based definition of metabolic syndrome has superior diagnostic value in detection of poor health-related quality of life? Cross-sectional findings from Tehran Lipid and Glucose Study

 

World Health Organization (WHO)

European Group for the study of Insulin Resistance (EGIR)

American Association of Clinical Endocrinology (AACE)

Absolutely required

IGTa or IFGb or IRc or diabetes

Plasma insulin > 75 percentile of persons without diabetes in the population under study.

High risk of being insulin resistant d (excluding diabetes)

Criteria

plus two or more of the below abnormalities

plus two or more of the four below abnormalities

Plus two or more of the four below abnormalities

Adiposity index

WHR > 0.90 in men and >0.85 in women and/or BMI > 30 kg/m2

WC ≥ 94 cm in men and ≥80 cm in women

none

Triglycerides

≥1.7 mmol/L and/or

>2 mmol/L and/or

>1.7 mmol/L

HDL

<0.9 mmol/L in men and <1.0 mmol/L in women

<1.0 mmol/L or treated for dyslipidemia

<1.0 mmol/L in men and <1.3 mmol/L in women.

Blood pressure

≥140/90 mmHg or treated for hypertension

≥140/90 mmHg or treated for hypertension

≥130/85 mmHg or treated for hypertension

Hyperglycemia

none

Fasting plasma glocuse ≥ 6.1 mmol/L (but without diabetes)

Fasting plasma glucose 6.1–6.9 mmol/L or IGT

  1. BMI, body mass index; WC, waist circumference; IGT, impaired glucose tolerance; IFG, impaired fasting glucose; HDL, high density lipoprotein; WHR, waist to hip ratio a120 min post glucose challenge (75 mg):7.8–11.1 mm/L bFasting plasma glucose 5.6–7.00 mm/L cdefined as plasma insulin > 75 percentile of persons without diabetes in the population under study dFor the AACE definition, high risk of being insulin resistant is indicated by the presence of at least one of the followings: diagnosis of hypertension or cardiovascular disease; family history of type 2 diabetes or history of gestational diabetes or glucose intolerance; BMI > 25 kg/m2 or WC > 94 cm (men), >80 cm (women); age >40 years