Table 1 Disease profiles of the moderate and severe cases of chronic metallic mercury vapor intoxication (CMMVI)
Disease label [a] | Chronic Metallic Mercury Vapor Intoxication (CMMVI) | |
|---|---|---|
Disease stage [b] | Moderate case | Severe case |
Disease-specific description (including exposure [c] and health situation [d]) | Adults with high mercury body burden caused by chronic inhalation of metallic mercury vapor who show several of the following symptoms: | Adults with a very high mercury body burden caused by chronic inhalation of metallic mercury vapor who show several of the following symptoms: |
• Slight tremor of fingers, hands, and limbs; coordination problems; dysfunction of movement control; weakness • Reflexes abnormalities; peripheral nerve abnormalities; sensory disturbances • Sleep disorders; irritability; nervousness; fatigue; memory impairment; difficulty in concentration; shyness; depressive mood; loss of confidence; lack of self-control • Renal effects like enzymuria, proteinuria, and glomerular dysfunction, increased urinary excretion of N-acetyl-β-glucosaminidase (NAG) • Loss of appetite; salivation • Immunological changes | • Pronounced tremor in several parts of the body; severe coordination problems; dysfunction of movement control; weakness • Polyneuropathy • Insomnia; hyperirritability; nervousness; fatigue; loss of memory; difficulty in concentration; extreme shyness; depression; loss of confidence; lack of self-control; social avoidance • Abnormal renal function with enzymuria, high proteinuria, glomerular dysfunction, and rising urinary excretion of N-acetyl-β-glucosaminidase (NAG) • Anorexia; excessive salivation; gingivitis; stomatitis • Immunological changes • Difficulty seeing | |
Generic description (EQ-5D + C [e]) | • No problems in walking (1) • Some problems with self-care (2) • No problems with performing usual activities (1) • Moderate pain or discomfort (2) • Moderately anxious or depressed (2) • Some problems in cognitive functions (2) | • Some problems in walking about (2) • Not able to wash or dress themselves (3) • Not able to perform usual activities (3) • Severe pain or discomfort (3) • Extremely anxious or depressed (3) • Severe problems in cognitive functions (3) |