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Table 1 Known-groups validity: the LS mean SOBDA weekly score by mMRC and by BDI response categories

From: A meta-analysis of four randomized clinical trials to confirm the reliability and responsiveness of the Shortness of Breath with Daily Activities (SOBDA) questionnaire in chronic obstructive pulmonary disease

ANCOVA excluding percent predicted FEV1 at screening

mMRC scorea at screening (Day -14 to -7)

mMRC, LS mean run-in Week 1 SOBDA score (SE); n

BDI score at randomization (Day 1)

BDI, LS mean baseline SOBDA score (SE); n

BDI score at randomization (Day 1)

BDI, LS mean baseline SOBDA score (SE); n

0–1

0

0

2.73 (0.108); 32

7

1.84 (0.021); 817

2

1.83 (0.012); 2939

1

2.63 (0.109); 31

8

1.65 (0.029); 434

3

2.25 (0.017); 1395

2

2.57 (0.056); 117

9

1.59 (0.035); 307

4

2.62 (0.050); 163

3

2.48 (0.031); 391

10

1.40 (0.060); 103

  

4

2.30 (0.029); 427

11

1.38 (0.115); 28

  

5

2.14 (0.027); 499

12

1.49 (0.106); 33

  

6

2.00 (0.017); 1276

  

Overall F-statistic (p-value)*

279.49 (<0.001)

  

Overall F-statistic (p-value)*

83.90 (<0.001)

  1. ANCOVA analysis of covariance, BDI Baseline Dyspnea Index, FEV 1 forced expiratory volume in 1 s, LS least squares, mMRC modified Medical Research Council Dyspnea Scale, SE standard error, SOBDA Shortness of Breath with Daily Activities
  2. aScore 0 = not troubled with breathlessness except during strenuous exercise to 4 = too breathless to leave the house or breathless when dressing or undressing
  3. *ANCOVA adjusted for age, gender, and geographical region (excluding % predicted FEV1)
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Health and Quality of Life Outcomes

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