Fig. 1

Change in the SOBDA prior week score by TDI (a), SGRQ (b), CAT (c), and trough FEV₁ (d) response. *Response was defined as a TDI focal score of at least 1 unit. ^†Response was defined as a change from baseline in SGRQ total score of ≤ −4. ^‡Response was defined as a change from baseline in CAT score of ≤ −2 (studies DB2113360 and DB211374 only). ^§Response was defined as a change from baseline in trough FEV₁ of ≥100 mL. Analyses performed using analysis of covariance adjusted for SOBDA baseline score and geographic region. Error bars represent the 95 % CIs. CAT, COPD Assessment Test; CI, confidence interval; COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 s; LS, least squares; SGRQ, St George’s Respiratory Questionnaire score; SOBDA, Shortness of Breath with Daily Activities; TDI, Transition Dyspnea Index