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Table 1 Clinical profiles of patients with polyneuropathy

From: Quality of life in polyneuropathy: association with biomarkers of small fiber impairment

Features Patients with neuropathy
Men/Women 38/23
Age (Mean ± SD) 58.14±12.95
Mean duration of disease (Interquartile range) 4 (1–6)
Neurological examinations  
Motor systema  
Upper limbs Proximal: 4.82 ± 0.59 / Distal: 4.68 ± 0.58 b
Lower limbs Proximal: 4.66 ± 0.84 / Distal: 4.42 ± 0.85 c
Sensory system  
Large-fiber sensory impairment  
Impaired proprioception 65.6 %
Impaired vibration sensation at ankles 65.6 %
Small-fiber sensory impairment  
Impaired pinprick sensation 80.3 %
Burning or tingling sensation 77.0 %
Other small fiber characteristics d 8.2 %
Autonomic system  
Gastrointestinal symptoms 32.8 %
Genitourinary symptoms 26.2 %
Orthostatic hypotension 29.5 %
Sudomotor failure 37.7 %
Etiology  
Diabetic polyneuropathy 10 (16.4 %)
Immune-related polyneuropathy e 11 (18.0 %)
Drug-induced polyneuropathy f 4 ( 6.6 %)
Inherited polyneuropathy g 10 (16.4 %)
Idiopathic polyneuropathy 26 (42.6 %)
  1. a:Muscle strength: according to Medical Research Council (MRC) grade
  2. b:Proximal muscle of upper limbs included abduction muscle of the shoulder. Distal muscles of upper limbs included flexion and extension muscles of the wrist and grasp of the hand
  3. c:Proximal muscle of lower limbs included hip flexion muscle. Distal muscles of lower limbs included dorsiflexion and plantar flexion muscles of the ankle
  4. d:Electric shock–like or cold-like pain
  5. e:Chronic inflammatory demyelinating polyneuropathy (5), Sjögren syndrome (2), vasculitic neuropathy (2), Guillain-Barré syndrome (1), IgM paraproteinemic neuropathy (1)
  6. f:Chemotherapy induced neuropathy (3): docetaxel (2), cisplatin (1) and metronidazole induced neuropathy (1)
  7. g:Charcot-Marie-Tooth disease (3), familial amyloid polyneuropathy (7)