Scale/Domain | Baseline n = 97 | 7 days n = 97 | 6 weeks n = 92 | 3 months n = 85 | 6 months n = 84 | 12 months n = 81 | 18 months n = 75 | Control group n = 81 |
---|---|---|---|---|---|---|---|---|
IOF QLQ | ||||||||
Pain | 69.7 (9.2) | 58.1 (11.5) p < 0.0001 | 22.0 (7.4) p < 0.0001 | 14.6 (10.1) p < 0.0001 | 10.4 (6.7) p < 0.0001 | 7.5 (8.9) p < 0.0001 | 6.2 (9.1) p < 0.0001 | 0 p < 0.0001 |
Upper limb symptoms | 44.7 (14.0) | 51.3 (13.6) p = 0.001 | 30.1 (10.7) p < 0.0001 | 21.4 (9.2) p < 0.0001 | 14.4 (11.5) p < 0.0001 | 3.7 (14.2) p < 0.0001 | 3.1 (11.5) p < 0.0001 | 0 p < 0.0001 |
Physical function | 82.8 (9.0) | 81.3 (11.6) p = 0.55 | 58.9 (15.2) p < 0.0001 | 33.1 (7.0) p < 0.0001 | 16.6 (13.4) p < 0.0001 | 9.7 (10.5) p < 0.0001 | 10.1 (11.1) p < 0.0001 | 12.1 (6.6) p < 0.0001 |
General health | 78.1 (13.7) | 83.1 (9.9) p = 0.004 | 60.8 (12.2) p < 0.0001 | 37.2 (18.6) p < 0.0001 | 20.7 (11.3) p < 0.0001 | 7.0 (4.9) p < 0.0001 | 7.3 (5.1) p < 0.0001 | 0 p < 0.0001 |
Overall score | 67.4 (10.2) | 65.9 (11.0) p = 0.33 | 48.3 (10.8) p < 0.0001 | 27.8 (9.7) p < 0.0001 | 16.1 (12.0) p < 0.0001 | 7.6 (10.4) p < 0.0001 | 6.8 (10.0) p < 0.0001 | 4.3 (2.7) p < 0.0001 |
SF-36 | ||||||||
PF | 59.7 (23.6) | 57.1 (24.0) p = 0.45 | 66.4 (27.2) p = 0.07 | 73.6 (23.5) p = 0.0001 | 77.3 (20.1) p < 0.0001 | 84.1 (19.0) p < 0.0001 | 85.9 (16.8) p < 0.0001 | 87.0 (12.9) p < 0.0001 |
RP | 15.1 (29.0) | 27.4 (28.6) p = 0.003 | 38.0 (25.3) p < 0.0001 | 52.8 (21.2) p < 0.0001 | 59.3 (19.2) p < 0.0001 | 74.2 (21.4) p < 0.0001 | 81.5 (20.7) p < 0.0001 | 84.3 (24.1) p < 0.0001 |
BP | 39.5 (27.1) | 42.7 (24.1) p = 0.39 | 79.3 (19.3) p < 0.0001 | 79.8 (18.5) p < 0.0001 | 84.7 (17.2) p < 0.0001 | 87.5 (11.4) p < 0.0001 | 87.2 (12.1) p < 0.0001 | 88.7 (15.4) p < 0.0001 |
GH | 63.5 (14.2) | 65.2 (15.7) p = 0.43 | 74.1 (21.3) p = 0.0001 | 73.2 (20.2) p = 0.0002 | 75.7 (18.2) p < 0.0001 | 79.0 (15.6) p < 0.0001 | 78.3 (14.9) p < 0.0001 | 78.2 (14.4) p < 0.0001 |
VT | 55.3 (16.9) | 61.3 (26.2) p = 0.06 | 68.6 (20.4) p < 0.0001 | 71.0 (15.4) p < 0.0001 | 72.6 (13.1) p < 0.0001 | 73.3 (14.8) p < 0.0001 | 72.6 (12.8) p < 0.0001 | 73.7 (13.6) p < 0.0001 |
SF | 51.7 (13.3) | 51.4 (18.5) p = 0.90 | 69.2 (24.8) p < 0.0001 | 80.3 (22.5) p < 0.0001 | 88.1 (17.0) p < 0.0001 | 88.7 (20.5) p < 0.0001 | 88.9 (18.2) p < 0.0001 | 89.2 (18.3) p < 0.0001 |
RE | 40.8 (17.0) | 47.3 (20.6) p = 0.02 | 74.8 (17.6) p < 0.0001 | 83.4 (16.4) p < 0.0001 | 86.2 (19.8) p < 0.0001 | 90.4 (17.3) p < 0.0001 | 91.3 (21.4) p < 0.0001 | 90.0 (22.8) p < 0.0001 |
MH | 67.4 (24.1) | 70.3 (22.2) p = 0.39 | 78.8 (19.7) p = 0.0005 | 84.1 (16.4) p < 0.0001 | 82.0 (17.9) p < 0.0001 | 81.1 (22.6) p < 0.0001 | 82.3 (19.3) p < 0.0001 | 82.5 (19.9) p < 0.0001 |
Gartland & Werley score | ||||||||
Excellent (%) | - | - | - | 42.4 % | 44.1 % | 51.9 % | 68.0 % | - |
Good (%) | - | - | - | 37.7 % | 35.7 % | 34.6 % | 20.0 % | - |
Poor (%) | - | - | - | 19.9 % | 20.2 % | 13.5 % | 12.0 % | - |