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Table 6 Comparison of change in CD4 count and QoL among 573 patients not receiving ART at the Mulago HIV clinic in Uganda between April 2012 and December 2013

From: Relationship between CD4 count and quality of life over time among HIV patients in Uganda: a cohort study

Outcome QoL score

PHS

MHS

GPGI

Predictor variable β coefficient/Odds Ratio (95 % CI)

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Change in CD4 count

−0.0003 (−0.0015 to 0.0010)

−0.0003 (−0.0011 to 0.0008)

−0.0001 (−0.0012 to 0.0009)

0.0000 (−0.0010 to 0.0011)

0.9991 (0.9983 to 0.9998)

0.9990 (0.9982 to 0.9997)

SE = 0.0006

SE = 0.0006

SE = 0.0005

SE = 0.0005

SE = 0.0004

SE = 0.0004

Gender

 Male

Ref

Ref

Ref

Ref

Ref

Ref

 Female

−0.56 (−1.11 to −0.14)

−0.71 (−1.33 to −0.09)

−0.13 (−0.58 to 0.33)

0.07 (−0.46 to 0.61)

1.13 (0.84 to 1.52)

1.26 (0.89 to 1.77)

Age in years

 <30

Ref

Ref

Ref

Ref

Ref

Ref

 30−39

−0.21 (−0.73 to 0.32)

−0.32 (−0.86 to 0.22)

0.39 (−0.05 to 0.83)

0.38 (−0.08 to 0.84)

0.78 (0.58 to 1.05)

0.79 (0.58 to 1.09)

 ≥40

−1.16 (−1.77 to −0.55)

−1.35 (−2.00 to −0.70)

0.29 (−0.22 to 0.81)

0.17 (−0.39 to 0.73)

0.62 (0.45 to 0.87)

0.62 (0.43 to 0.89)

Education level

 ≤Primary

Ref

Ref

Ref

Ref

Ref

Ref

 Secondary

0.74 (0.24 to 1.23)

0.66 (0.16 to 1.15)

0.12 (−0.29 to 0.54)

0.11 (−0.02 to 0.53)

1.51 (1.15 to 1.97)

1.26 (0.96 to 1.66)

 Apprenticeship

0.96 (0.04 to 1.87)

0.46 (−0.48 to 1.40)

−0.03 (−0.80 to 0.73)

−0.03 (−0.83 to 0.78)

1.75 (1.03 to 2.98)

1.50 (0.86 to 2.63)

 Tertiary

1.33 (−0.59 to 3.25

0.82 (−1.03 to 2.67)

−0.11 (−1.73 to 1.50)

0.06 (−1.54 to 1.65)

11.85 (1.73 to 80.95)

10.11 (1.52 to 67.14)

Marital status

 Currently married

Ref

Ref

Ref

Ref

Ref

Ref

 Divorced/separated

0.55 (−0.52 to 0.63)

0.22 (−0.36 to 0.81)

0.21 (−0.27 to 0.69)

0.22 (−0.28 to 0.72)

0.82 (0.60 to 1.12)

0.84 (0.61 to 1.15)

Single

−0.03 (−1.07 to 1.02)

−0.51 (−1.58 to 0.57)

−0.31 (−1.18 to 0.55)

−0.35 (−1.27 to 0.57)

1.07 (0.56 to 2.05)

0.82 (0.43 to 1.56)

Widowed

−0.26 (−1.05 to 0.53)

0.45 (−0.36 to 1.27)

−0.02 (−0.68 to 0.63)

0.11 (−0.60 to 0.81)

0.78 (0.52 to 1.17)

0.86 (0.54 to 1.38)

Alcohol consumption

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

 No

−0.23 (−0.73 to 0.28)

−0.02 (−0.52 to 0.49)

0.01 (−0.41 to 0.43)

0.10 (0.34 to 0.53)

0.93 (0.71 to 1.22)

0.94 (0.70 to 1.26)

Income per month in USD

 <20

Ref

Ref

Ref

Ref

Ref

Ref

 20−60

0.36 (−0.24 to 095)

0.41 (−0.30 to 1.11)

−0.22 (−0.72 to 0.27)

−0.66 (−1.27 to −0.06)

1.28 (0.93 to 1.77)

1.18 (0.82 to 1.70)

 >60

0.79 (0.23 to 1.35)

0.54 (−0.16 to 1.25)

−0.06 (−0.53 to 0.40)

−0.43 (−1.03 to 0.18)

1.60 (1.18 to 2.17)

1.33 (0.91 to 1.95)

Smoking status

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

 No

0.64 (−0.48 to 1.75)

0.27 (−0.88 to 1.42)

−0.72 (−1.64 to 0.20)

−0.87 (−1.85 to 0.12)

2.14 (1.19 to 3.84)

1.62 (0.91 to 2.89)

Depression score No depression

 (<16)

Ref

Ref

-

-

Ref

Ref

 Probable depression (≥16)

−1.07 (−1.46 to −0.67)

−1.01 (−1.41 to −0.60)

  

0.41 (0.33 to 0.52)

0.43 (0.33 to 0.55)

Social support

 Yes, family

Ref

Ref

Ref

Ref

Ref

Ref

 Yes, other

0.063 (−0.53 to 0.66)

0.003 (−0.60 to 0.60)

0.28 (−0.21 to 0.77)

0.41 (−0.11 to 0.92)

0.91 (0.67 to 1.24)

0.96 (0.69 to 1.33)

None

−0.01 (−1.12 to 1.10)

−0.01 (−1.10 to 1.07)

0.70 (−0.21 to 1.61)

0.65 (−0.28 to 1.58)

1.10 (0.62 to 1.95)

1.20 (0.65 to 2.20)

Opportunistic infection

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

 No

0.41 (−0.15 to 0.97)

0.22 (−0.36 to 0.79)

0.59 (0.12 to 1.06)

0.66 (0.17 to 1.16)

1.06 (0.78 to 1.45)

1.02 (0.73 to 1.42)

WHO stage

 Stages I and II

Ref

Ref

Ref

Ref

Ref

Ref

 Stages III and IV

−0.63 (−1.30 to 0.04)

−0.51 (−1.19 to 0.17)

0.38 (−0.94 to 0.18)

−0.19 (−0.77 to 0.40)

0.86 (0.59 to 1.25)

1.00 (0.68 to 1.45)

Religion

 Christian

Ref

Ref

Ref

Ref

Ref

Ref

 Muslim

−0.74 (−1.39 to −0.09)

−0.30 (−0.96 to 0.37)

0.27 (−0.27 to 0.81)

0.24 (−0.33 to 0.82)

1.03 (0.71 to 1.50)

1.19 (0.80

to 1.78)

 Other

−0.55 (−2.42 to 1.31)

−0.57 (−2.35 to 1.21)

1.13 (−0.42 to 2.68)

1.40 (−0.13 to 2.94)

1.11 (0.45 to 2.78)

0.82 (0.28 to 2.46)

Employment status

 Yes

Ref

Ref

Ref

Ref

Ref

Ref

 No

−0.28 (−0.87 to 0.31)

0.26 (−0.48 to 1.00)

−0.23 (−0.72 to 0.26)

−0.39 (−1.02 to 0.25)

0.70 (0.51 to 0.97)

0.73 (0.49 to 1.09)

  1. Abbreviations: 95 % CI, 95 % confidence interval; SE, standard error