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Table 4 Responsiveness of I-QOL and IUI across clinical criteria at week 12

From: Psychometric properties of the incontinence utility index among patients with idiopathic overactive bladder: data from two multicenter, double-blind, randomized, Phase 3, placebo-controlled clinical trials

  

Change scorea

p-value

SRMsb

Effect size

 

Number

Mean

SD

Lower limit

Upper limit

TBSc Greatly improve

        

- Abbreviated I-QOL

186

34.62

22.78

31.33

37.92

<0.001

1.52

1.87

- Original I-QOL

187

42.79

21.72

39.66

45.92

<0.001

1.97

2.24

- IUI

186

0.37

0.27

0.33

0.41

<0.001

1.37

2.56

TBS Improved

        

- Abbreviated I-QOL

274

18.14

19.64

15.76

20.40

<0.001

0.92

0.98

- Original I-QOL

274

22.80

19.82

20.40

25.08

<0.001

1.15

1.21

- IUI

274

0.16

0.19

0.14

0.19

<0.001

0.87

1.14

TBS Not changed

        

- Abbreviated I-QOL

462

1.90

15.86

0.56

3.47

0.017

0.12

0.11

- Original I-QOL

462

2.20

13.84

0.98

3.51

0.004

0.16

0.12

- IUI

462

0.02

0.13

0.00

0.03

0.031

0.12

0.12

TBS Worsened

        

- Abbreviated I-QOL

109

−0.73

15.97

−3.77

2.30

0.502

−0.05

−0.04

- Original I-QOL

109

−1.09

14.01

−3.75

1.57

0.376

−0.08

−0.06

- IUI

109

−0.01

0.13

−0.03

0.02

0.363

−0.05

−0.05

Responderd 50 % = 0 (No)

        

- Abbreviated I-QOL

552

2.79

16.86

1.49

4.36

<0.001

0.17

0.16

- Original I-QOL

552

2.82

14.89

1.65

4.19

<0.001

0.19

0.16

- IUI

552

0.02

0.14

0.01

0.03

<0.001

0.16

0.17

Responder 50 % = 1 (Yes)

        

- Abbreviated I-QOL

470

22.47

23.09

20.34

24.49

<0.001

0.97

1.19

- Original I-QOL

471

28.51

24.01

26.29

30.60

<0.001

1.19

1.50

- IUI

470

0.23

0.25

0.20

0.25

<0.001

0.90

1.52

Responder 75 % = 0 (No)

        

- Abbreviated I-QOL

697

5.05

17.89

3.77

6.46

<0.001

0.28

0.28

- Original I-QOL

697

5.85

17.29

4.61

7.20

<0.001

0.34

0.32

- IUI

697

0.04

0.15

0.03

0.05

<0.001

0.28

0.32

Responder 75 % = 1 (Yes)

        

- Abbreviated I-QOL

325

26.40

23.65

23.85

28.94

<0.001

1.12

1.41

- Original I-QOL

326

33.46

23.76

30.86

35.96

<0.001

1.41

1.75

- IUI

325

0.28

0.27

0.25

0.31

<0.001

1.05

1.80

Responder 100 % = 0 (No)

        

- Abbreviated I-QOL

843

7.38

19.10

6.12

8.72

<0.001

0.39

0.41

- Original I-QOL

843

9. 18

19.58

7.88

10.54

<0.001

0.47

0.50

- IUI

843

0.06

0.17

0.05

0.08

<0.001

0.38

0.48

Responder 100 % = 1 (Yes)

        

- Abbreviated I-QOL

179

32.85

23.97

29.21

36.12

<0.001

1.37

1.79

- Original I-QOL

180

40.26

22.99

36.69

43.30

<0.001

1.75

2.10

- IUI

179

0.36

0.28

0.32

0.40

<0.001

1.29

2.40

  1. aChange score = scores at week 12 minus scores at baseline
  2. bSRM: Standardized response means
  3. cTBS: Treatment Benefit Scale
  4. dResponder: calculated from the average percentage of reduction in daily UI episodes from baseline
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