Table 2 Clinical characteristics of the population-based study cohort
Total cohort, n = 837 | Dutch MG Cohort, n = 464 | Norwegian MG Cohort, n = 373 | P-value | Adjusted p-value | |
|---|---|---|---|---|---|
Female [n;%] | 491 (58.7) | 256 (55.2) | 235 (63.0) | 0.022 | 0.749 |
Age [mean ± SD] | 60.3 (17.6) | 61.2 (18)a | 59.2 (17.1)a | 0.099 | 0.215 |
Married /cohabiting | 572 (68.3) | 316 (68.1) | 256 (68.6) | 0.881 | 0.870 |
Single/divorced/widow | 265 (31.7) | 148 (31.9) | 117 (31.4) | ||
Mean age at onset [yrs ± SD] | 45.8 (21.3) | 49.1 (21.0) | 41.8 (20.9) | <0.001 | <0.001 |
Disease duration [yrs ± SD] | 12.6 (12.2) | 10.7 (11.0) | 15 (13.2) | <0.001 | <0.001 |
Antibody serology | |||||
AChR MG b | 693 (82.2) | 396 (85.3) | 297 (79.6) | <0.001 | <0.001 |
MuSK MGb | 20 (2.4) | 18 (3.9) | 2 (0.5) | ||
SNMGb | 115 (13.9) | 44 (9.7) | 71 (19) | ||
Missing n = 9 (0.9 %) | |||||
Thymoma MGb | 70 (21.2) | 34 (25) | 36 (18.8) | 0.181 | 0.077 |
Age at onset [n;%] | |||||
EOMG (<50 year) | 397 (47.5) | 196 (42.2) | 202 (54.2) | <0.001 | <0.001 |
LOMG (>50 year) | 398 (47.8) | 247 (53.2) | 151 (47.9) | ||
Juvenile MG (<16 years) | 41 (4.9) | 21 (4.5) | 20 (5.4) | ||
Disease course [n;%] | |||||
Remission | 196 (23.4) | 97 (20.9) | 99 (26.5) | <0.001 | <0.001 |
Ocular | 102 (12.2) | 75 (16.2) | 27 (7.2) | ||
Bulbar | 90 (10.4) | 44 (9.5) | 46 (12.3) | ||
Generalized | 449 (53.6) | 248 (53.4) | 201 (53.9) | ||
Current treatment [n;%]: | |||||
Pyridostigmine | 559 (66.8) | 322 (69.4) | 237 (63.5) | 0.074 | 0.074 |
Prednisolone | 279 (33.3) | 157 (33.8) | 122 (32.7) | 0.731 | 0.966 |
Immunosuppressives | 231 (27.6) | 127 (27.4) | 104 (28.0) | 0.851 | 0.887 |
Combined | 377 (45.0) | 212 (45.7) | 165 (44.0) | 0.675 | 0.662 |
SF-36 [mean ± SD] | |||||
Physical functioning | 64.4 (29.8) | 62.2 (30.7) | 67.1 (28.3) | 0.017 | 0.014 |
Role Physical | 51.8 (43.7) | 54.5 (44.0) | 48.3 (43.2) | 0.041 | 0.035 |
Bodily pain | 69.3 (28.0) | 72.6 (26.5) | 65.1 (29.4) | <0.001 | <0.001 |
General Health | 52.4 (15.6) | 52.7 (14.0) | 52.4 (17.0) | 0.802 | 0.896 |
Vitality | 51.9 (22.7) | 55.8 (21.3) | 47.2 (23.4) | <0.001 | <0.001 |
Social functioning | 72.6 (26.9) | 72.4 (26.4) | 73.0 (27.6) | 0.754 | 0.64 |
Role Emotional | 75.7 (38.6) | 79.5 (36.0) | 71.1 (41.3) | 0.002 | 0.002 |
Mental Health | 75.1 (18.1) | 73.4 (18.0) | 77.6 (17.7) | 0.001 | 0.001 |
Physical composite score | 59.4 (23.6) | 60.5 (23.0) | 58.4 (24.3) | 0.192 | 0.149 |
Mental composite score | 69.0 (21.2) | 70.3 (20.5) | 67.5 (22.0) | 0.053 | 0.064 |
Norm-based PCS | 42.4 (11.0) | 42.7 (11.1) | 42.0 (10.9) | 0.323 | 0.291 |
Norm-based MCS | 50.5 (9.4) | 50.6 (9.4) | 50.5 (9.4) | 0.905 | 0.902 |