Table 1 CFQ-R adjusted change scores from baseline through week 48 by treatment group
CFQ-R Scale | Placebo | Ivacaftor | ||||
|---|---|---|---|---|---|---|
(N = 70b) | (N = 80b) | |||||
Baseline | Change | Baseline | Change | Treatment effect | p-valuea | |
Body Image | 80.3 | −1.2 | 81.0 | 1.5 | 2.7 | 0.086 |
Digestive Symptoms | 85.4 | 0.4 | 85.2 | 0.8 | 0.5 | 0.732 |
Eating Problems | 91.9 | −1.1 | 91.8 | 2.2 | 3.3 | 0.002 |
Emotional Functioning | 83.6 | −1.4 | 86.0 | 0.7 | 2.1 | 0.096 |
Health Perceptions | 71.7 | −3.6 | 72.1 | 4.0 | 7.6 | <0.001 |
Physical Functioning | 80.2 | −1.7 | 76.1 | 2.7 | 4.4 | 0.006 |
Respiratory Symptoms | 68.5c | −2.7 | 70.2 | 5.9 | 8.6 | <0.001 |
Role Functioning | 85.9 | 0.1 | 86.3 | −0.5 | −0.6 | 0.651 |
Social Functioning | 71.9 | −1.0 | 72.1 | 3.3 | 4.3 | 0.003 |
Treatment Burden | 65.7 | 1.0 | 64.5 | 4.3 | 3.3 | 0.042 |
Vitality | 64.7 | −2.8 | 64.3 | 2.7 | 5.5 | 0.002 |
Weight | 78.1 | 1.7 | 79.0 | 6.9 | 5.3 | 0.053 |