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Table 5 Assessment of coverage of HAE attack warning signs by the HAE PRO

From: Development and content validity testing of a patient-reported outcomes questionnaire for the assessment of hereditary angioedema in observational studies

Warning signs assessed by HAE PRO and mentioned by patients Additional warning signs mentioned by patients (n = 43)
Skin redness (n = 13) Pain (n = 4)
Irritability (n = 11) Itchiness (n = 4)
Nausea (n = 8) Burning (n = 4)
Skin sensation (n = 7) None (n = 4)
Tiredness (n = 7) Feeling of butterflies (n = 3)
Skin Tightness (n = 6) Swelling (n = 3)
Aggressiveness (n = 3) Red rings on the skin (n = 3)
Sensitivity to noise (n = 3) Stress (n = 2)
Hunger (n = 2) Headaches (n = 2)
Prickling (n = 1) Thirst (n = 2)
  Difficulty breathing (n = 2)
  Numbness (n = 2)