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Table 1 Criteria for inclusion and exclusion

From: Health related quality of life in adolescents with chronic fatigue syndrome: a cross-sectional study

 

CFS patients

Healthy control subjects

Inclusion criteria:

Persisting or constantly relapsing fatigue lasting 3 months or more.

Age ≥ 12 years and < 18 years

 

Functional disability resulting from fatigue to a degree that prevent normal school attendance

 
 

Age ≥ 12 and < 18 years

 

Exclusion criteria:

Another current process or chronic disease or demanding life event that might explain the fatigue

Another chronic disease

Permanent use of pharmaceuticals (including hormones)

 

Permanent use of pharmaceuticals (including hormones) possibly interfering with the measurements

 
 

Permanently bed-ridden

 
 

Positive pregnancy test

 
 

Pheocromocytoma

 
 

Evidence of reduced cerebral and/or peripheral circulation due to vessel disease

 
 

Polyneuropathy

 
 

Renal insufficiency

 
 

Known hypersensitivity towards clonidine or inert substances (lactose, saccarose) in capsula

 
 

Abnormal ECG (apart from ectopic beats)

 
 

Supine heart rate < 50 beats/min

 
 

Supine systolic blood pressure < 85 mmHg

 
 

Upright systolic blood pressure fall > 30 mmHg

 
  1. The criteria are designed for the randomized control trial in the NorCAPITAL-project (The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial; Clinical Trials ID: NCT01040429), which explores possible mechanisms of CFS, the effect of low-dose clonidine treatment, and patients’ experiences as adolescents with CFS (9)