Dimensions | Capecitabine-based | 5-FU/LV-based | P valueb | |||||||
---|---|---|---|---|---|---|---|---|---|---|
n | Mean | SD | P valuea | n | Mean | SD | P valuea | |||
Physical | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 73.90 | 11.78 |  | 27 | 80.12 | 12.46 |  | 0.746 |
 | 28th week | 81 | 86.14 | 11.13 | <0.0001 | 27 | 86.12 | 11.48 | 0.038 | 0.657 |
Role | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 78.58 | 11.65 |  | 27 | 77.48 | 14.78 |  | 0.865 |
 | 28th week | 81 | 90.97 | 11.08 | <0.0001 | 27 | 86.77 | 14.31 | 0.001 | 0.582 |
Emotional | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 84.45 | 8.54 |  | 27 | 83.88 | 7.57 |  | 0.537 |
 | 28th week | 81 | 90.24 | 7.56 | <0.0001 | 27 | 89.93 | 6.10 | <0.0001 | 0.357 |
Cognitive | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 88.18 | 7.42 |  | 27 | 88.58 | 8.30 |  | 0.091 |
 | 28th week | 81 | 92.55 | 7.29 | <0.0001 | 27 | 87.77 | 6.93 | 0.641 | 0.331 |
Social | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 83.15 | 8.58 |  | 27 | 82.75 | 11.85 |  | 0.313 |
 | 28th week | 81 | 84.86 | 9.06 | 0.226 | 27 | 91.03 | 8.98 | 0.002 | 0.532 |
Global health status | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 62.93 | 6.59 |  | 27 | 59.61 | 8.98 |  | 0.517 |
 | 28th week | 81 | 75.58 | 5.64 | <0.0001 | 27 | 74.76 | 4.97 | <0.0001 | 0.854 |
Fatigue | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 25.11 | 10.49 |  | 27 | 25.80 | 8.81 |  | 0.884 |
 | 28th week | 81 | 9.34 | 10.53 | <0.0001 | 27 | 17.59 | 9.63 | 0.002 | 0.259 |
Nausea and Vomiting | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 3.91 | 9.41 |  | 27 | 6.77 | 10.74 |  | 0.467 |
 | 28th week | 81 | 6.56 | 9.96 | 0.002 | 27 | 6.81 | 10.89 | 0.982 | 0.187 |
Pain | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 11.75 | 8.36 |  | 27 | 8.41 | 7.61 |  | 0.421 |
 | 28th week | 81 | 4.63 | 6.24 | <0.0001 | 27 | 4.07 | 6.13 | 0.058 | 0.746 |
Dyspnea | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 8.82 | 8.62 |  | 27 | 6.00 | 9.61 |  | 0.087 |
 | 28th week | 81 | 6.64 | 5.13 | 0.029 | 27 | 4.90 | 8.52 | 0.536 | 0.689 |
Insomnia | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 22.16 | 15.78 |  | 27 | 18.50 | 13.71 |  | 0.050 |
 | 28th week | 81 | 16.15 | 11.96 | 0.002 | 27 | 17.19 | 11.73 | 0.603 | 0.382 |
Appetite loss | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 10.44 | 10.91 |  | 27 | 19.64 | 12.17 |  | 0.004 |
 | 28th week | 81 | 11.10 | 14.75 | 0.696 | 27 | 11.67 | 16.08 | 0.006 | 0.476 |
Constipation | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 14.31 | 12.40 |  | 27 | 6.36 | 11.67 |  | 0.057 |
 | 28th week | 81 | 14.28 | 7.64 | 0.982 | 27 | 6.24 | 6.53 | 0.951 | 0.273 |
Diarrhea | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 13.88 | 16.39 |  | 27 | 13.82 | 14.39 |  | 0.581 |
 | 28th week | 81 | 9.05 | 14.78 | 0.002 | 27 | 12.91 | 13.16 | 0.783 | 0.276 |
Financial difficulties | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 | Baseline | 81 | 6.06 | 6.70 |  | 27 | 7.45 | 7.24 |  | 0.666 |
 | 28th week | 81 | 6.05 | 10.20 | 0.990 | 27 | 4.83 | 10.33 | 0.118 | 0.040 |