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Table 2 Anchor-based approach for determining minimally important differences for the EQ-5D and SF-6D indices

From: Estimation of minimally important differences in the EQ-5D and SF-6D indices and their utility in stroke

  Modified rankin Scale based Barthel ADL index based
  N Mean change (SD) (time2-time1) P-value SRM ES N Mean change (SD) (time2-time1) P-value SRM ES
EQ-5D index             
  All 484 −0.04 (0.27) 0.003 0.15 0.07 442 −0.05 (0.26) 0.001 0.17 0.08
  Sizeable better 17 0.17 (0.26) 0.015 0.66 0.71 23 0.23 (0.31) <0.001 0.76 0.72
  Minimally better 86 0.08* (0.21) <0.001 0.38 0.28 27 0.09* (0.28) 0.048 0.32 0.31
  No change 220 −0.01 (0.22) 0.413 0.06 0.03 281 −0.01 (0.19) 0.471 0.06 0.03
  Minimally worse 115 −0.12* (0.26) <0.001 0.47 0.46 53 −0.12* (0.23) <0.001 0.50 0.43
  Sizeable worse 46 −0.27 (0.26) <0.001 0.75 0.84 58 −0.33 (0.34) <0.001 0.97 1.27
P-value§   <0.001       <0.001     
SF-6D index             
  All 484 0.01 (0.14) 0.520 0.04 0.01 442 0.01 0.14 0.334 0.05 0.01
  Sizeable better 19 0.16 (0.13) 0.002 1.21 1.33 23 0.14 (0.12) <0.001 1.17 1.40
  Minimally better 86 0.07* (0.13) <0.001 0.52 0.58 27 0.14* (0.15) <0.001 0.92 1.11
  No change 220 0.01 (0.13) 0.296 0.07 0.08 281 0.01 (0.14) 0.373 0.05 0.08
  Minimally worse 115 −0.04* (0.12) <0.001 0.33 0.36 53 −0.04* (0.13) 0.068 0.27 0.33
  Sizeable worse 46 −0.08 (0.12) <0.001 0.50 0.53 58 −0.06 (0.12) <.0001 0.53 0.55
P-value§   <0.001      <0.001      
  1. SRM = standardized response mean; ES = effect size.
  2. *These scores are estimates of the MID.
  3. P-value by Wilcoxon signed rank test.
  4. §P-value by Kruskal Wallis test.