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Table 3 Baseline and change in scores of the JOQOL in postmenopausal Japanese women with osteoporosis stratified by minimal clinically important change in VAS pain

From: Responsiveness of the Japanese Osteoporosis Quality of Life questionnaire in women with postmenopausal osteoporosis

  MCIC (VAS pain reduction) Baseline Change in score at 24 weeks*
n Mean (SD) n Mean (SD) pvalue
Pain ≥ 20 mm 145 12.3 (4.4) 109 4.1 (4.7) < 0.001
< 20 mm 248 14.9 (4.4) 163 0.3 (3.5)
Activities of daily living ≥ 20 mm 148 46.0 (13.4) 110 6.1 (9.3) < 0.001
< 20 mm 250 53.8 (11.8) 165 -1.3 (7.1)
Recreation/social activities ≥ 20 mm 143 8.2 (4.8) 104 0.4 (4.3) 0.215
< 20 mm 242 9.3 (4.8) 160 -0.2 (4.1)
Overall health ≥ 20 mm 152 4.7 (2.0) 118 1.7 (2.4) < 0.001
< 20 mm 264 5.4 (2.2) 183 0.6 (2.1)
Posture/physique ≥ 20 mm 146 9.8 (3.6) 109 0.6 (2.7) 0.219
< 20 mm 241 10.8 (3.9) 153 0.2 (2.7)
Falls/psychological factors ≥ 20 mm 151 11.3 (4.1) 116 1.8 (3.6) < 0.001
< 20 mm 254 12.4 (4.0) 177 0.2 (3.0)
Total score ≥ 20 mm 133 61.0 (15.7) 93 9.7 (12.2) < 0.001
< 20 mm 201 70.4 (14.8) 120 -0.3 (9.0)
  1. Abbreviations: JOQOL Japanese Osteoporosis Quality of Life questionnaire, MCIC minimal clinically important change, SD standard deviation, SRM standardized response mean, VAS visual analogue scale.
  2. *Change from baseline to last observation carried forward; Determined by two-sample t-test.