Responsiveness of the Japanese Osteoporosis Quality of Life questionnaire in women with postmenopausal osteoporosis

Table 3 Baseline and change in scores of the JOQOL in postmenopausal Japanese women with osteoporosis stratified by minimal clinically important change in VAS pain

	MCIC (VAS pain reduction)	Baseline		Change in score at 24 weeks*
	MCIC (VAS pain reduction)	n	Mean (SD)	n	Mean (SD)	pvalue^†
Pain	≥ 20 mm	145	12.3 (4.4)	109	4.1 (4.7)	< 0.001
Pain	< 20 mm	248	14.9 (4.4)	163	0.3 (3.5)	< 0.001
Activities of daily living	≥ 20 mm	148	46.0 (13.4)	110	6.1 (9.3)	< 0.001
Activities of daily living	< 20 mm	250	53.8 (11.8)	165	-1.3 (7.1)	< 0.001
Recreation/social activities	≥ 20 mm	143	8.2 (4.8)	104	0.4 (4.3)	0.215
Recreation/social activities	< 20 mm	242	9.3 (4.8)	160	-0.2 (4.1)	0.215
Overall health	≥ 20 mm	152	4.7 (2.0)	118	1.7 (2.4)	< 0.001
Overall health	< 20 mm	264	5.4 (2.2)	183	0.6 (2.1)	< 0.001
Posture/physique	≥ 20 mm	146	9.8 (3.6)	109	0.6 (2.7)	0.219
Posture/physique	< 20 mm	241	10.8 (3.9)	153	0.2 (2.7)	0.219
Falls/psychological factors	≥ 20 mm	151	11.3 (4.1)	116	1.8 (3.6)	< 0.001
Falls/psychological factors	< 20 mm	254	12.4 (4.0)	177	0.2 (3.0)	< 0.001
Total score	≥ 20 mm	133	61.0 (15.7)	93	9.7 (12.2)	< 0.001
Total score	< 20 mm	201	70.4 (14.8)	120	-0.3 (9.0)	< 0.001

Abbreviations: JOQOL Japanese Osteoporosis Quality of Life questionnaire, MCIC minimal clinically important change, SD standard deviation, SRM standardized response mean, VAS visual analogue scale.
*Change from baseline to last observation carried forward; ^†Determined by two-sample t-test.

ISSN: 1477-7525