Validation and comparison of EuroQoL-5 dimension (EQ-5D) and Short Form-6 dimension (SF-6D) among stable angina patients

Table 4 Efficiency of the EQ-5D and SF-6D to detect clinically relevant difference

Measure	SAQ	N	Mean (SD)	Effect size^a	t Test		RE^b	ROC curve
Measure	SAQ	N	Mean (SD)	Effect size^a	t statistic	P		AUC	95%CI
EQ-5D	Physical limitation
EQ-5D	>= 50	351	0.81 (0.13)	1.126*	8.062	0.000	1.000	0.762*	(0.690, 0.834)
	<50	60	0.65 (0.20)
SF-6D	Physical limitation
SF-6D	>= 50	351	0.69 (0.11)	0.981*	7.020	0.000	0.758	0.765*	(0.710, 0.820)
	<50	60	0.59 (0.10)
EQ-5D	Angina stability
EQ-5D	>=50	232	0.82 (0.14)	0.587*	5.901	0.000	1.000	0.660*	(0.607, 0.712)
	<50	179	0.74 (0.14)
SF-6D	Angina stability
SF-6D	>=?50	232	0.71 (0.11)	0.706*	7.100	0.000	1.448	0.694*	(0.643, 0.744)
	<50	179	0.63 (0.11)
EQ-5D	Angina frequency
EQ-5D	>=?50	313	0.80 (0.16)	0.426*	3.677	0.000	1.000	0.662*	(0.606, 0.717)
	<50	98	0.74 (0.10)
SF-6D	Angina frequency
SF-6D	>=?50	313	0.69 (0.11)	0.573*	4.953	0.000	1.814	0.661*	(0.601, 0.722)
	<50	98	0.63 (0.11)
EQ-5D	Treatment satisfaction
EQ-5D	>=?50	323	0.80 (0.15)	0.495*	4.120	0.000	1.000	0.664*	(0.609, 0.719)
	<50	88	0.73 (0.12)
SF-6D	Treatment satisfaction
SF-6D	>=?50	323	0.70 (0.11)	0.778*	6.466	0.000	2.463	0.724*	(0.667, 0.781)
	<50	88	0.61 (0.10)
EQ-5D	Disease perception
EQ-5D	>=?50	318	0.81 (0.14)	0.707*	5.998	0.000	1.000	0.696*	(0.640, 0.751)
	<50	93	0.71 (0.13)
SF-6D	Disease perception
SF-6D	>=?50	318	0.71 (0.11)	1.179*	9.997	0.000	2.778	0.814*	(0.767, 0.860)
	<50	93	0.58 (0.10)

*P< 0.001. For ROC curve, P< 0.001 indicates that AUC statistically significantly greater than 0.5.
^aEffect sizes were computed as the difference between the means of the groups divided by the pooled standard deviation.
^bReference is EQ-5D measure.
EQ-5D: EuroQol-5D; SF-6D: Short form-6D; SAQ: Seattle Angina Questionnaire; SD: standard deviation; ROC: receiver operating characteristics; RE: relative efficiency; AUC: area under ROC curves; CI: confidence interval.

ISSN: 1477-7525