| |
Insulin-experienced, N = 1,966
|
Insulin-naïve, N = 6,612
|
Total cohort, N = 8,578
|
---|
HbA1c (%)
|
N
|
1056
|
3386
|
4442
|
Baseline
|
9.1 (2.3)
|
9.6 (2.2)
|
9.5 (2.3)
|
Week 24
|
7.0 (1.1)
|
7.0 (1.0)
|
7.0 (1.0)
|
Change
|
-2.0 (2.2)
|
-2.7 (2.2)
|
-2.5 (2.2)
|
P value
|
<0.001
|
<0.001
|
<0.001
|
Body weight (kg)
|
N
|
1459
|
4600
|
6059
|
Baseline
|
68.7 (11.2)
|
68.5 (11.3)
|
68.5 (11.3)
|
Week 24
|
69.2 (10.9)
|
68.8 (10.8)
|
68.9 (10.8)
|
Change
|
0.5 (3.0)
|
0.3 (3.1)
|
0.3 (3.1)
|
P value
|
<0.001
|
<0.001
|
<0.001
|
Overall hypoglycaemia (events/patient year)
|
N
|
1966
|
6612
|
8578
|
Baseline
|
6.12
|
1.2
|
2.32
|
Week 24
|
2.14
|
1.37
|
1.54
|
Nocturnal hypoglycaemia (events/patient year)
|
N
|
1966
|
6612
|
8578
|
Baseline
|
1.65
|
0.26
|
0.58
|
Week 24
|
0.42
|
0.24
|
0.28
|
Major hypoglycaemia (events/patient year)
|
N
|
1966
|
6612
|
8578
|
Baseline
|
0.37
|
0.09
|
0.15
|
Week 24
|
0.00
|
0.00
|
0.00
|
Minor hypoglycaemia (events/patient year)
|
N
|
1966
|
6612
|
8578
|
Baseline
|
5.75
|
1.10
|
2.17
|
Week 24
|
2.14
|
1.37
|
1.54
|
- Data are mean (sd), n or incidence.