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Table 8 Responsiveness: change in HIT-6 scores in relation to changes in clinical criterion measures

From: Validation of the Headache Impact Test (HIT-6) in patients with chronic migraine

Decrease from baseline in headache days at week 24
  Mean change in HIT-6 SD n SRM F-valuea F-valueb
Study 1      
  ≥50% −6.9 7.63 255 −0.90   
  ≥30% to <50% −3.3 5.18 141 −0.64   
  <30% −0.7 4.23 283 −0.17 148.81* 148.33*
Study 2      
  ≥50% −6.9 8.07 291 −0.86   
  ≥30% to <50% −2.9 5.60 131 −0.52   
  <30% −0.7 4.01 283 −0.18 140.01* 139.62*
Decrease from Baseline in Cumulative Hours of Headache Occurring on Headache Days at Week 24
  Mean Change in HIT-6 SD n SRM F-value a F-value b
Study 1      
  ≥50% −6.9 7.50 269 −0.92   
  ≥30% to <50% −2.6 5.24 115 −0.50   
  <30% −0.9 4.30 295 −0.21 142.06* 143.15*
Study 2      
  ≥50% −6.5 8.05 319 −0.81   
  ≥30% to <50% −2.2 4.64 109 −0.47   
  <30% −0.9 4.41 277 −0.20 112.72* 112.07*
  1. *P-value <0.001.
  2. aF-Statistics and P-values for between-category comparisons are from analysis of variance (ANOVA). The main effect in the ANOVA was ranked category of decrease in the clinical criterion measure (i.e., headache days or cumulative hours), where the type III sum of squares was used.
  3. bF-Statistics and P-values for between-category comparisons are from analysis of variance (ANOVA). The main effects in the ANOVA included ranked category of decrease in the clinical criterion measure (i.e., headache days or cumulative hours) and medication-overuse strata, where the type III sum of squares was used.
  4. HIT-6 = Headache Impact Test-6; SD = standard deviation; SRM = standardized response mean.