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Table 7 Known-groups validity: HIT-6 scores at week 24 in relation to clinical criterion measures

From: Validation of the Headache Impact Test (HIT-6) in patients with chronic migraine

Number of headache days
  <10 Days 10–14 Days ≥15 Days    
Study Mean SD N Mean SD N Mean SD N   Fa Fb
1 58.4 (8.18) 257 62.9 (5.48) 154 65.0 (5.70) 268   125.02* 125.28*
2 58.2 (8.21) 288 63.3 (6.33) 171 64.6 (5.17) 246   120.71* 114.87*
Cumulative Hours of Headache
  Quartile 1: <140 hours Quartile 2: 140 to <280 hours Quartile 3: 280 to <420 hours Quartile 4: ≥420 hours   
Study Mean SD N Mean SD N Mean SD N Mean SD N F a F b
1 59.1 (7.74) 313 63.6 (5.78) 186 65.5 (5.27) 106 65.9 (6.27) 74 105.97* 110.12*
2 59.2 (8.08) 357 63.5 (5.80) 199 64.8 (5.15) 90 66.0 (5.49) 59 89.50* 88.38*
  1. *P-value <0.001.
  2. aF-Statistics and P-values for between-category comparisons are from analysis of variance (ANOVA). The main effect in the ANOVA was ranked category of decrease in the clinical criterion measure (i.e., headache days or cumulative hours), where the type III sum of squares was used.
  3. bF-Statistics and P-values for between-category comparisons are from ANOVA. The main effects in the ANOVA included ranked category of decrease in the clinical criterion measure (i.e., headache days or cumulative hours) and medication-overuse strata, where the type III sum of squares was used.
  4. HIT-6 = Headache Impact Test-6; SD = standard deviation.