Skip to main content

Table 3 Content and face validity of each patient-reported outcome measure

From: Patient-reported outcome measures for systemic lupus erythematosus clinical trials: a review of content validity, face validity and psychometric performance

PRO Instrument Content and face validity evaluated with SLE patients using cognitive debriefing methodology Item wording acceptable Recall period acceptable for patient population Response options acceptable
SLE-specific HRQoL     
SLAQ
LupusQoL
LupusPRO
L-QoL
SLEQOL ✗ ‘Fatigue’ not defined ✗ Confusing
Generic HRQoL     
SF-36v2
EQ-5D#
Fatigue     
FACIT-Fatigue
MFI ✗ ‘Lately’ too vague ✗ Confusing
MAF ✗ ‘Fatigue’ not defined ✗ Confusing
Pain     
MPQ ✗ Complex terms used ✗ Complex terms used
BPI-SF ✗ Some items don’t specify recall
Depression     
BDI ✗ No question wording ✗ None specified ✗ Lengthily
HADS
Work productivity     
WPAI:Lupus ✗ Some complex terms used
  1. SLAQ – Systemic Lupus Activity Questionnaire, SF-36v2 – Short Form [36] Health Survey, EQ-5D – EuroQol 5-Dimensions, FACIT-Fatigue - Functional Assessment of Chronic Illness Therapy, MFI – Multidimensional Fatigue Inventory, MAF – Multidimensional Assessment of Fatigue, MGQ – McGill Pain Scale, BPI – Brief Pain Inventory, BDI – Beck Depression Inventory, HADS – Hospital Anxiety and Depression Scale, WPAI:Lupus – Work Productivity and Activity Impairment Questionnaire: Lupus. #Result valid for both the EQ-5D-3L and EQ-5D-5L.