|
Concept identified in literature review
|
SLE-specific HRQoL
|
Generic HRQoL
|
Fatigue
|
Pain
|
Depression
|
Work
|
|---|
| |
SLAQ
|
LupusQoL$
|
LupusPRO$
|
L-QoL
|
SLEQOL
|
SF-36v2
|
EQ-5D#
|
FACIT-Fatigue
|
MFI
|
MAF
|
MPQ
|
BPI-SF
|
BDI
|
HADS
|
WPAI: Lupus
|
|---|
|
Disease-defining signs and symptoms
|
|
Marks on skin
| ✓ | | | | | | | | | | | | | | |
|
Weight gain/bloating
| ✓ | ✓ | | | | | | | | | | | | | |
|
Hair loss
| ✓ | ✓ | ✓ | | | | | | | | | | | | |
|
Looking sick
| | | | | | | | | | | | | | | |
|
Reduced cognitive function
| ✓ | ✓ | ✓ | | ✓ | | | | ✓ | | | | | | |
|
Fatigue
| ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | | ✓* | ✓* | ✓* | | | ✓ | | |
|
Pain
| ✓ | | ✓ | | ✓ | ✓ | ✓ | | | | ✓ | ✓ | | | |
|
Fever
| ✓ | | | | | | | | | | | | | | |
|
Weakness
| | | | | | ✓ | | ✓* | ✓* | | | | | | |
|
Flu-like symptoms
| | | | | | | | | | | | | | | |
|
Impacts
|
|
Physical functioning
| | ✓ | ✓ | | ✓ | ✓ | ✓ | | ✓* | ✓* | | ✓* | | | |
|
Daily activities
| | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓* | ✓* | ✓* | | ✓* | | | ✓ |
|
Sleep problems
| | ✓ | | | | ✓ | | ✓* | ✓* (p) | | | ✓* | | | |
|
Emotional/Psychological
| ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓* | | ✓* (p) | | ✓* | ✓ | ✓ | |
|
Social functioning
| | ✓ | | ✓ | ✓ | ✓ | | ✓* | ✓* (p) | ✓* | | | | | |
|
Leisure activities
| | ✓ | | | ✓ | ✓ | | | ✓* | ✓* | | | | | |
|
Relationships
| | ✓ | | ✓ | | ✓ | | | | ✓ (p) | | ✓* | | | |
|
Work & economic impacts
|
|
Work disability
| | | ✓ | | ✓ | ✓ | | | | ✓* | | ✓* | | | ✓ |
|
Economic impact
| | | ✓ | | ✓ | ✓ | | | | | | | | | |
|
Total
|
8/27
|
11/27
|
9/27
|
5/27
|
10/27
|
12/27
|
4/27
|
6/27
|
8/27
|
8/27
|
1/27
|
7/27
|
2/27
|
1/27
|
2/27
|
- SLAQ – Systemic Lupus Activity Questionnaire, SF-36v2 – Short Form [36] Health Survey, EQ-5D – EuroQol 5-Dimensions, FACIT-Fatigue - Functional Assessment of Chronic Illness Therapy, MFI – Multidimensional Fatigue Inventory, MAF – Multidimensional Assessment of Fatigue, MGQ – McGill Pain Scale, BPI – Brief Pain Inventory, BDI – Beck Depression Inventory, HADS – Hospital Anxiety and Depression Scale, WPAI:Lupus – Work Productivity and Activity Impairment Questionnaire: Lupus.
- ~ The following symptoms were identified as important in the literature review, but are not measured by current PROs: flu-like symptoms, dry mouth, skin rash, speech problems, vision sensitivity to bright lights, sensitivity to hot/cold temperatures, reduced hand grip, haematological abnormalities, sleep related respiratory and movement problems $PRO measure has documented evidence of qualitative research with patients with SLE during item generation #Result valid for both the EQ-5D-3L and EQ-5D-5L *Concept assessed only as a fatigue related impact (p) Concept partially covered by one or more items.
