Table 2 Types of ADEs reported at category level for studies using different assessment methods (number of studies presented in table)

Gastrointestinal

9

14

3

5

Neurology

3

6

1

3

Cardiac General

9

9

4

1

4

Blood/Bone Marrow

2

4

5

1

Pulmonary/Upper Respiratory

1

2

2

Hepatobiliary/Pancreas

3

7

1

11

2

Auditory/Ear

1

1

Ocular/Visual

1

Dermatology/Skin

1

4

3

Musculoskelal/Soft Tissue

1

1

Renal/Genitourinary

1

1

2

2

Constitutional symptoms:

- weight

6

12

- other

1

3

1

Pain

3

7

2

Endocrine

1

Infection

1

3

Allergy/Immunology

1

Sexual/Reproductive Function

1

Metabolic:

- hypoglycaemia

7

7

8

3

5

- other

4

1

7

1

General ADEs/Tolerability*

3

12

3

3

5