Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer

Table 2 Test-retest reliability (ICC) of the QLQ-C30, QLQ-CR38 and FACT-C for patients with stable colorectal cancer undergoing chemotherapy (data obtained between the third and the fourth treatment)

	n	ICC^a	95% CI^b
EORTC QLQ-C30:
*Functional scales:*
Physical function	34	0.87	0.76-0.93
Role function	33	0.80	0.64-0.90
Emotional function	34	0.73	0.52-0.85
Cognitive function	34	0.79	0.62-0.89
Social function	34	0.84	0.71-0.92
Global QoL/GHS	34	0.33	-0.01-0.59
*Symptom scales:*
Fatigue	34	0.82	0.67-0.90
Pain	34	0.74	0.54-0.86
Nausea and vomiting	34	0.43	0.11-0.67
*Single items* ^c :
Dyspnoea	34	0.63	0.37-0.79
Sleep disturbance	34	0.76	0.58-0.87
Appetite loss	34	0.74	0.54-0.86
Diarrhoea	34	0.33	-0.003-0.60
Constipation	34	0.54	0.25-0.74
Financial impact	34	0.75	0.56-0.87
EORTC QLQ-CR38:
*Functional scales:*
Body image	32	0.71	0.49-0.85
Future perspective	32	0.76	0.56-0.87
Sexual functioning	31	0.82	0.66-0.91
Sexual enjoyment	11	NA	NA
*Symptom scales:*
Radiation-induced effects micturition	32	0.67	0.43-0.82
Chemotherapy side effects	32	0.70	0.47-0.84
General gastrointestinal symptoms	32	0.65	0.39-0.81
Defecation problems	26	NA	NA
Stoma-related problems	6	NA	NA
Sexual dysfunction of men	14	NA	NA
Sexual dysfunction of women	3	NA	NA
Weight loss	32	0.36	0.02-0.63
FACT-C:
Physical Well-Being	34	0.76	0.57-0.87
Social/Family Well-Being	33	0.51	0.23-0.73
Emotional Well-Being	34	0.79	0.62-0.89
Functional Well-Being	34	0.73	0.52-0.85
Colorectal Cancer Specific	34	0.77	0.59-0.90
FACT-C total score	34	0.75	0.55-0.87
Trial Outcome Index-Colorectal	34	0.82	0.66-0.90

^a Intraclass correlation coefficient; ^b confidence interval; NA: Not Applicable (n < 30)

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