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Table 5 Change in QoL Measures and Associated HRs for Death

From: Can changes in health related quality of life scores predict survival in stages III and IV colorectal cancer?

Change Variable QoL Change Mean (SD) Univariate Multivariate
   HR (95% CI) P HR (95% CI) P
General Quality of Life      
Global -1.8 (29.0) 1.00 (0.95 - 1.04) 0.93 0.99 (0.95 - 1.04) 0.81
General Function      
Physical -2.0 (24.5) 0.96 (0.91 - 1.01) 0.14 0.86 (0.78 - 0.94) 0.001*
Role -3.1 (38.3) 1.02 (0.99 - 1.05) 0.25 Not used  
Emotional 1.5 (28.9) 1.00 (0.96 - 1.04) 0.99 1.01 (0.95 - 1.07) 0.70
Cognitive -0.50 (27.9) 1.01 (0.96 - 1.05) 0.69 0.99 (0.92 - 1.06) 0.74
Social 0.84 (36.9) 1.03 (1.00 - 1.07) 0.08 1.08 (1.02 - 1.13) 0.008*
General Symptom      
Fatigue 1.7 (34.3) 0.99 (0.95 - 1.02) 0.50 0.98 (0.90 - 1.05) 0.55
Nausea/Vomiting 2.0 (29.4) 1.01 (0.97 - 1.06) 0.61 1.03 (0.97 - 1.09) 0.39
Pain -1.6 (37.2) 1.00 (0.96 - 1.03) 0.95 1.01 (0.96 - 1.07) 0.68
Dyspnea 0.34 (32.4) 0.98 (0.94 - 1.02) 0.38 0.98 (0.93 - 1.03) 0.46
Insomnia 1.9 (40.8) 1.00 (0.97 - 1.04) 0.88 1.0 (0.95 - 1.04) 0.84
Appetite Loss 0.76 (37.9) 0.98 (0.95 - 1.02) 0.38 0.96 (0.91 - 1.01) 0.12
Constipation 0.25 (34.2) 1.02 (0.99 - 1.06) 0.19 1.02 (0.98 - 1.07) 0.29
Diarrhea 1.9 (33.7) 0.99 (0.94 - 1.03) 0.56 1.02 (0.98 - 1.07) 0.26
Financial 3.0 (39.9) 1.00 (0.97 - 1.04) 0.78 1.01 (0.97 - 1.04) 0.79
  1. • HRs correspond to a 10-point increment for QoL scores
  2. • 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined
  3. • Multivariate model (for change in general function and symptom variables combined) adjusted for age, gender, stage at diagnosis, prior treatment history and all QoL change variables excepting role function change
  4. • Multivariate model for change in global QoL adjusted for age, gender, stage at diagnosis and prior treatment history
  5. • *P < 0.05