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Table 3 Baseline QoL Measures and Associated HRs for Death

From: Can changes in health related quality of life scores predict survival in stages III and IV colorectal cancer?

Baseline Variable QoL Score Mean (SD) Univariate Multivariate
   HR (95% CI) P HR (95% CI) P
General Quality of Life      
Global 62.6 (24.0) 0.92 (0.87 - 0.98) 0.008* 0.93 (0.87 - 0.98) 0.01*
General Function      
Physical 78.6 (20.7) 0.96 (0.89 - 1.02) 0.16 1.08 (0.97 - 1.20) 0.14
Role 70.3 (30.3) 0.97 (0.92 - 1.02) 0.21 Not used  
Emotional 70.6 (22.7) 1.0 (0.94 - 1.06) 0.92 1.01 (0.92 - 1.09) 0.86
Cognitive 79.7 (22.0) 0.99 (0.94 - 1.05) 0.85 1.02 (0.93 - 1.12) 0.61
Social 68.4 (31.1) 0.96 (0.91 - 1.0) 0.04* 0.93 (0.86 - 1.01) 0.08
General Symptom      
Fatigue 38.8 (27.9) 1.04 (0.99 - 1.08) 0.14 1.01 (0.90 - 1.11) 0.91
Nausea/Vomiting 13.4 (22.3) 0.99 (0.93 - 1.05) 0.84 0.95 (0.87 - 1.03) 0.18
Pain 29.3 (30.6) 1.03 (0.99 - 1.08) 0.12 1.02 (0.95 - 1.08) 0.64
Dyspnea 19.5 (26.2) 1.06 (1.01 - 1.11) 0.02* 1.05 (0.99 - 1.12) 0.09
Insomnia 33.7 (31.8) 1.03 (0.99 - 1.07) 0.17 1.04 (0.99 - 1.10) 0.12
Appetite Loss 25.2 (31.2) 1.05 (1.0 - 1.09) 0.03* 1.07 (1.01 - 1.14) 0.02*
Constipation 17.5 (27.4) 0.96 (0.91 - 1.02) 0.17 0.94 (0.88 - 1.00) 0.06
Diarrhea 15.4 (24.1) 1.07 (1.02 - 1.12) 0.01* 1.01 (0.95 - 1.07) 0.64
Financial 32.5 (32.9) 0.99 (0.95 - 1.03) 0.67 0.98 (0.92 - 1.03) 0.44
  1. • HRs correspond to a 10-point increment for QoL scores
  2. • 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined
  3. • Multivariate model (for general function and symptom variables combined) adjusted for age, gender, stage at diagnosis, prior treatment history and all baseline QoL variables excepting role function
  4. • Multivariate model for global QoL adjusted for age, gender, stage at diagnosis and prior treatment history
  5. • *P < 0.05