Can changes in health related quality of life scores predict survival in stages III and IV colorectal cancer?

Table 3 Baseline QoL Measures and Associated HRs for Death

Baseline Variable	QoL Score Mean (SD)	Univariate		Multivariate
		HR (95% CI)	P	HR (95% CI)	P
General Quality of Life
Global	62.6 (24.0)	0.92 (0.87 - 0.98)	0.008*	0.93 (0.87 - 0.98)	0.01*
General Function
Physical	78.6 (20.7)	0.96 (0.89 - 1.02)	0.16	1.08 (0.97 - 1.20)	0.14
Role	70.3 (30.3)	0.97 (0.92 - 1.02)	0.21	Not used
Emotional	70.6 (22.7)	1.0 (0.94 - 1.06)	0.92	1.01 (0.92 - 1.09)	0.86
Cognitive	79.7 (22.0)	0.99 (0.94 - 1.05)	0.85	1.02 (0.93 - 1.12)	0.61
Social	68.4 (31.1)	0.96 (0.91 - 1.0)	0.04*	0.93 (0.86 - 1.01)	0.08
General Symptom
Fatigue	38.8 (27.9)	1.04 (0.99 - 1.08)	0.14	1.01 (0.90 - 1.11)	0.91
Nausea/Vomiting	13.4 (22.3)	0.99 (0.93 - 1.05)	0.84	0.95 (0.87 - 1.03)	0.18
Pain	29.3 (30.6)	1.03 (0.99 - 1.08)	0.12	1.02 (0.95 - 1.08)	0.64
Dyspnea	19.5 (26.2)	1.06 (1.01 - 1.11)	0.02*	1.05 (0.99 - 1.12)	0.09
Insomnia	33.7 (31.8)	1.03 (0.99 - 1.07)	0.17	1.04 (0.99 - 1.10)	0.12
Appetite Loss	25.2 (31.2)	1.05 (1.0 - 1.09)	0.03*	1.07 (1.01 - 1.14)	0.02*
Constipation	17.5 (27.4)	0.96 (0.91 - 1.02)	0.17	0.94 (0.88 - 1.00)	0.06
Diarrhea	15.4 (24.1)	1.07 (1.02 - 1.12)	0.01*	1.01 (0.95 - 1.07)	0.64
Financial	32.5 (32.9)	0.99 (0.95 - 1.03)	0.67	0.98 (0.92 - 1.03)	0.44

• HRs correspond to a 10-point increment for QoL scores
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined
• Multivariate model (for general function and symptom variables combined) adjusted for age, gender, stage at diagnosis, prior treatment history and all baseline QoL variables excepting role function
• Multivariate model for global QoL adjusted for age, gender, stage at diagnosis and prior treatment history
• *P < 0.05

ISSN: 1477-7525