| Mixed Model Results | |||
---|---|---|---|---|
Endpoint | Change over time since Diagnosis (Interval) | Change at Disease Progression (Progression) | Change with Proximity to Progression (Proximity) | Main or Interaction Effects involving Regimen Group a |
PCM Items | Â | Â | Â | Â |
   Fatigue | Improving (p = .02) | Worsened (p = .004) | No effect | Progression: H = NT > T (p = .052)b |
   Pain | No effect | Worsened (p = .051) | No effect | No effect |
   Trouble Sleeping | No effect | No effect | No effect | Main effect: H = NT < T (p = .001) |
PCM Index Scores | Â | Â | Â | Â |
   General Physical Symptoms | Improving (p < .001) | Worsened (p < .001) | Tended to worsen leading into progression, with less improvement leading out (p = .088) | No effect |
   Treatment Side Effects | Improving (p = .013) | Worsened (p < .001) | No main effect | Proximity: H = NT < T (p = .005) [Taxane had worse scores distal from progression] |
   Acute Distress | Improving (p = .002); improving faster after progression (p = .022) | Worsened (p = .002) | No effect | No effect |
   Despair and Depression | No effect | No effect | No effect | No effect |
   Impaired Ambulation | No effect | No effect | No effect | No effect |
   Impaired Performance | Improving (p = .003) | Worsened (p = .003) | No effect | Main effect: H < NT (p = .005) > T (p = .004) |