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Table 6 Baseline to Week 12 mean changes in patient-reported outcomes according to ASAS working group response criteria

From: Psychometric characteristics of the short form 36 health survey and functional assessment of chronic illness Therapy-Fatigue subscale for patients with ankylosing spondylitis

Patient-reported outcome measure

ASAS Response

ASAS Response

ASAS Response

ASAS Response

p-value

 

Nonresponder

ASAS20

ASAS50

ASAS70

 

Mean change from baseline to Week 12 (SE)

Effect Size (ES)

     

FACIT-Fatigue

-0.24 (0.95)

9.42 (1.24)

14.33 (1.89)

15.20 (2.50)

< 0.0001

FACIT-Fatigue

ES = 0.02

ES = 0.92

ES = 1.40

ES = 1.49

< 0.0001

FACIT-Fatigue

n = 54

n = 12

n = 6

n = 10

< 0.0001

SF-36

     

   PCS

0.79 (0.42)

6.36 (1.00)

11.38 (1.12)

14.28 (0.77)

<0.0001

   PCS

ES = 0.10

ES = 0.81

ES = 1.44

ES = 1.81

< 0.0001

   PCS

n = 217

n = 63

n = 42

n = 60

< 0.0001

   MCS

0.54 (0.70)

3.33 (1.24)

1.86 (1.70)

9.61 (1.14)

< 0.0001

   MCS

ES = 0.05

ES = 0.30

ES = 0.17

ES = 0.86

< 0.0001

   MCS

n = 217

n = 63

n = 42

n = 60

< 0.0001

   Physical function

0.48 (1.11)

14.82 (1.98)

17.30 (2.90)

25.34 (2.72)

< 0.0001

   Physical function

ES = 0.02

ES = 0.67

ES = 0.79

ES = 1.15

< 0.0001

   Physical function

n = 222

n = 64

n = 43

n = 60

< 0.0001

   Role- physical

5.31 (1.80)

22.66 (4.16)

37.21 (6.30)

55.00 (4.40)

< 0.0001

   Role- physical

ES = 0.18

ES = 0.77

ES = 1.27

ES = 1.88

< 0.0001

   Role- physical

n = 223

n = 64

n = 43

n = 60

< 0.0001

   Bodily pain

3.03 (0.96)

17.50 (2.18)

30.40 (2.97)

41.02 (2.24)

< 0.0001

   Bodily pain

ES = 0.19

ES = 1.11

ES = 1.92

ES = 2.60

< 0.0001

   Bodily pain

n = 223

n = 64

n = 43

n = 60

< 0.0001

   General health

-0.12 (0.93)

4.78 (1.84)

13.19 (2.50)

21.40 (2.17)

< 0.0001

   General health

ES = 0.01

ES = 0.24

ES = 0.66

ES = 1.07

< 0.0001

   General health

n = 221

n = 63

n = 42

n = 60

< 0.0001

   Vitality

2.50 (1.07)

13.52 (1.84)

18.49 (2.68)

31.56 (2.36)

< 0.0001

   Vitality

ES = 0.14

ES = 0.77

ES = 1.05

ES = 1.79

< 0.0001

   Vitality

n = 222

n = 64

n = 43

n = 60

< 0.0001

   Social function

1.79 (1.36)

11.91 (2.62)

9.01 (3.36)

27.08 (2.63)

< 0.0001

   Social function

ES = 0.07

ES = 0.49

ES = 0.37

ES = 1.12

< 0.0001

   Social function

n = 223

n = 64

n = 43

n = 60

< 0.0001

   Role- emotional

3.32 (2.88)

13.54 (5.74)

15.50 (7.87)

32.22 (4.95)

< 0.0001

   Role- emotional

ES = 0.08

ES = 0.32

ES = 0.36

ES = 0.76

< 0.0001

   Role- emotional

n = 221

n = 64

n = 43

n = 60

< 0.0001

   Mental health

-0.01 (1.09)

5.98 (1.63)

4.23 (2.54)

17.20 (1.77)

< 0.0001

   Mental health

ES = 0.00

ES = 0.32

ES = 0.23

ES = 0.92

< 0.0001

   Mental health

n = 222

n = 64

n = 43

n = 60

< 0.0001

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Health and Quality of Life Outcomes

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