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Table 6 Baseline to Week 12 mean changes in patient-reported outcomes according to ASAS working group response criteria

From: Psychometric characteristics of the short form 36 health survey and functional assessment of chronic illness Therapy-Fatigue subscale for patients with ankylosing spondylitis

Patient-reported outcome measure ASAS Response ASAS Response ASAS Response ASAS Response p-value
  Nonresponder ASAS20 ASAS50 ASAS70  
Mean change from baseline to Week 12 (SE)
Effect Size (ES)
     
FACIT-Fatigue -0.24 (0.95) 9.42 (1.24) 14.33 (1.89) 15.20 (2.50) < 0.0001
FACIT-Fatigue ES = 0.02 ES = 0.92 ES = 1.40 ES = 1.49 < 0.0001
FACIT-Fatigue n = 54 n = 12 n = 6 n = 10 < 0.0001
SF-36      
   PCS 0.79 (0.42) 6.36 (1.00) 11.38 (1.12) 14.28 (0.77) <0.0001
   PCS ES = 0.10 ES = 0.81 ES = 1.44 ES = 1.81 < 0.0001
   PCS n = 217 n = 63 n = 42 n = 60 < 0.0001
   MCS 0.54 (0.70) 3.33 (1.24) 1.86 (1.70) 9.61 (1.14) < 0.0001
   MCS ES = 0.05 ES = 0.30 ES = 0.17 ES = 0.86 < 0.0001
   MCS n = 217 n = 63 n = 42 n = 60 < 0.0001
   Physical function 0.48 (1.11) 14.82 (1.98) 17.30 (2.90) 25.34 (2.72) < 0.0001
   Physical function ES = 0.02 ES = 0.67 ES = 0.79 ES = 1.15 < 0.0001
   Physical function n = 222 n = 64 n = 43 n = 60 < 0.0001
   Role- physical 5.31 (1.80) 22.66 (4.16) 37.21 (6.30) 55.00 (4.40) < 0.0001
   Role- physical ES = 0.18 ES = 0.77 ES = 1.27 ES = 1.88 < 0.0001
   Role- physical n = 223 n = 64 n = 43 n = 60 < 0.0001
   Bodily pain 3.03 (0.96) 17.50 (2.18) 30.40 (2.97) 41.02 (2.24) < 0.0001
   Bodily pain ES = 0.19 ES = 1.11 ES = 1.92 ES = 2.60 < 0.0001
   Bodily pain n = 223 n = 64 n = 43 n = 60 < 0.0001
   General health -0.12 (0.93) 4.78 (1.84) 13.19 (2.50) 21.40 (2.17) < 0.0001
   General health ES = 0.01 ES = 0.24 ES = 0.66 ES = 1.07 < 0.0001
   General health n = 221 n = 63 n = 42 n = 60 < 0.0001
   Vitality 2.50 (1.07) 13.52 (1.84) 18.49 (2.68) 31.56 (2.36) < 0.0001
   Vitality ES = 0.14 ES = 0.77 ES = 1.05 ES = 1.79 < 0.0001
   Vitality n = 222 n = 64 n = 43 n = 60 < 0.0001
   Social function 1.79 (1.36) 11.91 (2.62) 9.01 (3.36) 27.08 (2.63) < 0.0001
   Social function ES = 0.07 ES = 0.49 ES = 0.37 ES = 1.12 < 0.0001
   Social function n = 223 n = 64 n = 43 n = 60 < 0.0001
   Role- emotional 3.32 (2.88) 13.54 (5.74) 15.50 (7.87) 32.22 (4.95) < 0.0001
   Role- emotional ES = 0.08 ES = 0.32 ES = 0.36 ES = 0.76 < 0.0001
   Role- emotional n = 221 n = 64 n = 43 n = 60 < 0.0001
   Mental health -0.01 (1.09) 5.98 (1.63) 4.23 (2.54) 17.20 (1.77) < 0.0001
   Mental health ES = 0.00 ES = 0.32 ES = 0.23 ES = 0.92 < 0.0001
   Mental health n = 222 n = 64 n = 43 n = 60 < 0.0001