Heath-related quality of life in thyroid cancer patients following radioiodine ablation

Taïeb, David; Baumstarck-Barrau, Karine; Sebag, Frédéric; Fortanier, Cécile; De Micco, Catherine; Loundou, Anderson; Auquier, Pascal; Palazzo, Fausto F; Henry, Jean-françois; Mundler, Olivier

doi:10.1186/1477-7525-9-33

Table 2 Associations between 9-month FACIT scores/dimensions and sociodemographics, baseline clinical characteristics

	FACIT-F	FACIT-G	FACIT F TOI	PWB	SWB	EWB	FWB	FS
	[0-160]	[0-108]	[0-108]	[0-28]	[0-28]	[0-24]	[0-28]	[0-52]
Gender*
Men	131.64 ± 15.91	87.14 ± 11.43	90.10 ± 10.95	25.00 ± 2.59	21.81 ± 5.52	19.75 ± 2.56	20.58 ± 3.96	44.50 ± 7.76
Women	118.10 ± 27.62	80.26 ± 16.54	78.34 ± 21.55	22.51 ± 5.26	21.14 ± 5.28	18.67 ± 4.14	17.94 ± 5.67	37.98 ± 11.76
p	0.026	0.172	0.008	0.017	0.690	0.396	0.126	0.070
Age group*
< 45 y	128.91 ± 17.70	86.29 ± 11.73	86.32 ± 14.50	23.79 ± 4.67	23.12 ± 3.58	19.34 ± 3.38	20.04 ± 4.72	42.39 ± 7.31
> = 45 y	113.86 ± 29.90	77.48 ± 17.73	75.68 ± 23.26	22.09 ± 5.34	19.88 ± 5.95	18.42 ± 4.36	17.09 ± 5.68	36.66 ± 13.16
p	0.009	0.012	0.020	0.164	0.005	0.338	0.023	0.020
Educational level*
Middle school	116.29 ± 24.85	79.57 ± 14.59	76.92 ± 19.80	22.29 ± 5.23	20.83 ± 4.77	18.70 ± 3.43	17.74 ± 4.97	37.12 ± 11.28
High school	122.21 ± 27.36	82.20 ± 16.75	81.82 ± 21.08	23.19 ± 4.92	21.45 ± 5.57	18.90 ± 4.22	18.65 ± 5.79	39.96 ± 11.51
p	0.358	0.492	0.328	0.455	0.625	0.832	0.488	0.305
Marital status*
Single	115.00 ± 28.40	78.70 ± 16.90	76.07 ± 22.25	22.52 ± 5.31	20.69 ± 5.04	18.24 ± 4.21	17.24 ± 5.89	36.31 ± 12.13
Partner	123.35 ± 25.10	82.82 ± 15.43	82.65 ± 19.45	23.10 ± 4.87	21.56 ± 5.44	19.18 ± 3.78	18.98 ± 5.22	40.63 ± 10.81
p	0.182	0.272	0.178	0.622	0.484	0.311	0.178	0.109
Number of children*
0	123.50 ± 25.83	83.67 ± 17.18	82.00 ± 19.27	23.39 ± 5.28	22.56 ± 4.33	18.94 ± 4.40	18.78 ± 5.67	39.83 ± 9.18
> = 1	119.20 ± 26.87	80.61 ± 15.72	79.61 ± 21.19	22.74 ± 4.97	20.85 ± 5.51	18.80 ± 3.84	18.21 ± 5.50	38.75 ± 12.11
p	0.551	0.479	0.670	0.631	0.232	0.895	0.705	0.727
Occupational status*
Not working	121.49 ± 24.53	81.62 ± 14.53	81.48 ± 19.41	23.19 ± 4.73	20.46 ± 5.83	19.55 ± 2.85	18.42 ± 5.14	39.87 ± 11.18
Worker or student	119.34 ± 28.01	80.93 ± 17.35	79.28 ± 21.62	22.59 ± 5.31	21.82 ± 4.98	18.24 ± 4.52	18.28 ± 5.90	38.41 ± 11.7
p	0.908	0.998	0.681	0.680	0.273	0.279	0.369	0.533
Initial remnant ablation*
Hypo#	119.22 ± 23.99	80.14 ± 14.01	79.84 ± 18.80	22.87 ± 4.78	21.01 ± 4.42	18.36 ± 3.69	17.90 ± 4.64	39.08 ± 10.78
rhTSH##	121.17 ± 29.06	82.44 ± 17.84	80.49 ± 22.56	22.90 ± 5.29	21.47 ± 6.06	19.30 ± 4.17	18.78 ± 6.26	38.92 ± 12.19
p	0.749	0.526	0.892	0.980	0.703	0.292	0.481	0.953
Depression*
No	130.25 ± 22.07	87.82 ± 13.36	87.00 ± 17.72	23.84 ± 4.49	23.57 ± 3.47	19.70 ± 3.75	20.72 ± 5.10	42.48 ± 9.88
Yes	108.16 ± 26.66	73.51 ± 15.55	71.97 ± 21.17	21.75 ± 5.42	18.46 ± 5.76	17.81 ± 3.97	15.50 ± 4.60	34.83 ± 11.92
p	<0.001	<0.001	0.001	0.065	<0.001	0.033	<0.001	0.003
Anxiety level**	-0.389	-0.408	-0.355	-0.250	-0.315	-0.326	-0.422	-0.326
p	<0.001	<0.001	0.002	0.027	0.005	0.003	<0.001	0.004
Interval surgery/¹³¹I**	0.005	0.010	-0.020	0.032	0.046	0.074	-0.098	-0.003
p	0.964	0.932	0.866	0.784	0.696	0.533	0.408	0.978
Baseline QOL**	0.574	0.618	0.531	0.385	0.601	0.483	0.630	0.473
p	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

#Hypo: ¹³¹I during hypothyroidism, ##rhTSH: ¹³¹I after rhTSH injections
PWB Physical well-being, SWB Social/family well-being, EWB Emotional well-being, FWB Functional well-being, FS Fatigue
FACIT-G (PWB, SWB, EWB, and FWB subscales), FACIT-F (FACT-G, and FS subscale), FACIT-F TOI (PWB, FWB, and FS subscales) the higher the score, the higher the QOL level
* mean ± standard deviation, p: p-value Student's t-test or Mann-Whitney test
** Pearson's correlation coefficient, p: p-value Pearson's test
Bold values: p < 0.05

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ISSN: 1477-7525

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